Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
GATA2 and leukemia are reported together in 2 articles.
Gene
GATA2
- HGNC
- HGNC:4171
11articles
11mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency.
PMID 40749668 | PMCID PMC12365849 | DOI 10.1016/j.stemcr.2025.102596 · Stem cell reports · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GATA2 | “Clinical GATA2 haploinsufficiency results in immunodeficiency that evolves to leukemia.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Clinical GATA2 haploinsufficiency results in immunodeficiency that evolves to leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ASXL1 | “Our data further suggest that secondary mutations like ASXL1 exploit this impaired HSC genomic integrity to nurture a pre-leukemic state in GATA2 haploinsufficiency syndromes.” | 0.98 | hgnc_dict_v1 |
Clinical Validation of the Somatic FANCD2 Mutation (c.2022-5C>T) as a Novel Molecular Biomarker for Early Disease Progression in Chronic Myeloid Leukemia: A Case-Control Study.
PMID 39051418 | PMCID PMC11270283 | DOI 10.3390/hematolrep16030045 · Hematology reports · 2024 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GATA2 | “Although some markers of disease progression like BCR-ABL kinase domain, ASXL1, and GATA2 mutations are available, no universal and exclusively specific molecular biomarkers exist to early diagnose CML patients at risk of CML progression for timely therapeutic interventions to delay or minimize blast crisis transformation in CML.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Clinical Validation of the Somatic FANCD2 Mutation (c.2022-5C>T) as a Novel Molecular Biomarker for Early Disease Progression in Chronic Myeloid Leukemia: A Case-Control Study.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | FANCD2 | “Clinical Validation of the Somatic FANCD2 Mutation (c.2022-5C>T) as a Novel Molecular Biomarker for Early Disease Progression in Chronic Myeloid Leukemia: A Case-Control Study.” | 0.98 | hgnc_dict_v1 |
| gene | ASXL1 | “Although some markers of disease progression like BCR-ABL kinase domain, ASXL1, and GATA2 mutations are available, no universal and exclusively specific molecular biomarkers exist to early diagnose CML patients at risk of CML progression for timely therapeutic interventions to delay or minimize blast crisis transformation in CML.” | 0.98 | hgnc_dict_v1 |