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GFAP and Alzheimer disease are reported together in 2 articles.
Gene
GFAP
- HGNC
- HGNC:4235
53articles
53mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Revealing genetic links of Type 2 diabetes that lead to the development of Alzheimer's disease.
PMID 36711310 | PMCID PMC9876837 | DOI 10.1016/j.heliyon.2022.e12202 · Heliyon · 2023 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GFAP | “RESULTS: We screened the most important shared genes (CDKN1A, COL22A1, EIF4A, GFAP, SLC1A1, and VIM) and essential human molecular pathways that motivate these diseases.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Revealing genetic links of Type 2 diabetes that lead to the development of Alzheimer's disease.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CDKN1A | “RESULTS: We screened the most important shared genes (CDKN1A, COL22A1, EIF4A, GFAP, SLC1A1, and VIM) and essential human molecular pathways that motivate these diseases.” | 0.98 | hgnc_dict_v1 |
| gene | COL22A1 | “RESULTS: We screened the most important shared genes (CDKN1A, COL22A1, EIF4A, GFAP, SLC1A1, and VIM) and essential human molecular pathways that motivate these diseases.” | 0.98 | hgnc_dict_v1 |
Cytokine Storm and Neuropathological Alterations in Patients with Neurological Manifestations of COVID-19.
PMID 36089786 | DOI 10.2174/1567205019666220908084559 · Current Alzheimer research · 2022 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GFAP | “Biomarker studies on CSF and plasma and serum from COVID-19 patients have also shown a high level of IL-6, intrathecal IgG, neurofilament light chain (NFL), glial fibrillary acidic protein (GFAP), and tau protein.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “The association of the aforementioned cytokines with the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, may increase COVID-19 patients' risk of developing neurodegenerative diseases.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | COVID-19 | “Cytokine Storm and Neuropathological Alterations in Patients with Neurological Manifestations of COVID-19.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | stroke | “Neurological COVID-19 manifestations include loss of smell and taste, headache, dizziness, stroke, and potentially fatal encephalitis.” | 0.98 | phenotype_alias_lexicon_v2 |