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GFAP and diabetes mellitus are reported together in 4 articles.
Gene
GFAP
- HGNC
- HGNC:4235
53articles
53mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Revealing genetic links of Type 2 diabetes that lead to the development of Alzheimer's disease.
PMID 36711310 | PMCID PMC9876837 | DOI 10.1016/j.heliyon.2022.e12202 · Heliyon · 2023 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GFAP | “RESULTS: We screened the most important shared genes (CDKN1A, COL22A1, EIF4A, GFAP, SLC1A1, and VIM) and essential human molecular pathways that motivate these diseases.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Revealing genetic links of Type 2 diabetes that lead to the development of Alzheimer's disease.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CDKN1A | “RESULTS: We screened the most important shared genes (CDKN1A, COL22A1, EIF4A, GFAP, SLC1A1, and VIM) and essential human molecular pathways that motivate these diseases.” | 0.98 | hgnc_dict_v1 |
| gene | COL22A1 | “RESULTS: We screened the most important shared genes (CDKN1A, COL22A1, EIF4A, GFAP, SLC1A1, and VIM) and essential human molecular pathways that motivate these diseases.” | 0.98 | hgnc_dict_v1 |
Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in alleviating allodynia and hyperalgesia.
PMID 32676893 | DOI 10.1007/s12272-020-01249-8 · Archives of pharmacal research · 2020 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GFAP | “The spinal cords were evaluated for synaptic plasticity (growth associated protein-43, GAP43), microglia cell expression (by CD11b) and astrocyte expression (glial fibrillary acidic protein, GFAP).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Nine weeks after induction of diabetes, symptoms of neuropathy were confirmed and carbamazepine (or vehicle) was given every other day for five weeks.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | GAP43 | “Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in alleviating allodynia and hyperalgesia.” | 0.98 | hgnc_dict_v1 |
Neuroprotective effect of levetiracetam in mouse diabetic retinopathy: Effect on glucose transporter-1 and GAP43 expression.
PMID 31226418 | DOI 10.1016/j.lfs.2019.116588 · Life sciences · 2019 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GFAP | “Retinal tissues were dissected and paraffin-fixed for examination using (1) morphometric analysis with haematoxylin and eosin (HE), (2) immunohistochemistry (GLUT1, GFAP and GAP43), and (3) RT-PCR-detected expression of retinal inflammatory and apoptotic mediators (TNF-α, IL6, iNOS, NF-κB and Tp53).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “AIMS: Retinopathy is a neurodegenerative complication associating diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | GAP43 | “Neuroprotective effect of levetiracetam in mouse diabetic retinopathy: Effect on glucose transporter-1 and GAP43 expression.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Retinal tissues were dissected and paraffin-fixed for examination using (1) morphometric analysis with haematoxylin and eosin (HE), (2) immunohistochemistry (GLUT1, GFAP and GAP43), and (3) RT-PCR-detected expression of retinal inflammatory and apoptotic mediators (TNF-α, IL6, iNOS, NF-κB and Tp53).” | 0.98 | hgnc_dict_v1 |
Neuroprotective effect of duloxetine in a mouse model of diabetic neuropathy: Role of glia suppressing mechanisms.
PMID 29763613 | DOI 10.1016/j.lfs.2018.05.025 · Life sciences · 2018 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GFAP | “The effect of duloxetine was assessed in terms of pain responses, histopathology of sciatic nerve and spinal cord, sciatic nerve growth factor (NGF) gene expression and on the spinal expression of astrocytes (glial fibrillary acidic protein, GFAP) and microglia (CD11b).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “AIMS: Painful diabetic neuropathy (PDN) is one of the most frequent complications of diabetes and the current therapies have limited efficacy.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | NGF | “The effect of duloxetine was assessed in terms of pain responses, histopathology of sciatic nerve and spinal cord, sciatic nerve growth factor (NGF) gene expression and on the spinal expression of astrocytes (glial fibrillary acidic protein, GFAP) and microglia (CD11b).” | 0.98 | hgnc_dict_v1 |