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GLE1 and amyotrophic lateral sclerosis are reported together in 1 article.
Gene
GLE1
- HGNC
- HGNC:4315
2articles
2mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Amyotrophic lateral sclerosis
105articles
105mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Deficiency in the mRNA export mediator Gle1 impairs Schwann cell development in the zebrafish embryo.
PMID 26921650 | DOI 10.1016/j.neuroscience.2016.02.039 · Neuroscience · 2016 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GLE1 | “GLE1 mutations cause lethal congenital contracture syndrome 1 (LCCS1), a severe autosomal recessive fetal motor neuron disease, and more recently have been associated with amyotrophic lateral sclerosis (ALS).” | 0.98 | hgnc_dict_v1 |
| phenotype | amyotrophic lateral sclerosis | “GLE1 mutations cause lethal congenital contracture syndrome 1 (LCCS1), a severe autosomal recessive fetal motor neuron disease, and more recently have been associated with amyotrophic lateral sclerosis (ALS).” | 0.98 | phenotype_alias_lexicon_v2 |