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GLI1 and hepatocellular carcinoma are reported together in 2 articles.
Gene
GLI1
- HGNC
- HGNC:4317
19articles
19mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Hepatocellular carcinoma
417articles
417mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Itraconazole halts hepatocellular carcinoma progression by modulating sonic hedgehog signaling in rats: A novel therapeutic approach.
PMID 38176308 | DOI 10.1016/j.prp.2023.155086 · Pathology, research and practice · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GLI1 | “Our findings revealed that itraconazole exhibited a multifaceted arsenal against HCC by downregulating the expression of key components of the hedgehog pathway, shh, smoothened (SMO), and GLI family zinc finger 1 (GLI1), and GLI2.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Itraconazole halts hepatocellular carcinoma progression by modulating sonic hedgehog signaling in rats: A novel therapeutic approach.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SMO | “Our findings revealed that itraconazole exhibited a multifaceted arsenal against HCC by downregulating the expression of key components of the hedgehog pathway, shh, smoothened (SMO), and GLI family zinc finger 1 (GLI1), and GLI2.” | 0.98 | hgnc_dict_v1 |
| gene | GLI2 | “Our findings revealed that itraconazole exhibited a multifaceted arsenal against HCC by downregulating the expression of key components of the hedgehog pathway, shh, smoothened (SMO), and GLI family zinc finger 1 (GLI1), and GLI2.” | 0.98 | hgnc_dict_v1 |
Effects of mesenchymal stem cells versus curcumin on sonic hedgehog signaling in experimental model of Hepatocellular Carcinoma.
PMID 38874802 | DOI 10.1007/s11033-024-09613-3 · Molecular biology reports · 2024 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GLI1 | “Histopathological examinations were performed, and gene expression of SHH signaling target genes (SHH, PTCH1, SMOH, and GLI1) was assessed by real-time PCR in rat liver tissue.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatocellular carcinoma | “Effects of mesenchymal stem cells versus curcumin on sonic hedgehog signaling in experimental model of Hepatocellular Carcinoma.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTCH1 | “Histopathological examinations were performed, and gene expression of SHH signaling target genes (SHH, PTCH1, SMOH, and GLI1) was assessed by real-time PCR in rat liver tissue.” | 0.98 | hgnc_dict_v1 |