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GLI1 and prostate cancer are reported together in 2 articles.
Gene
GLI1
- HGNC
- HGNC:4317
19articles
19mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Prostate cancer
218articles
218mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Carvacrol instigates intrinsic and extrinsic apoptosis with abrogation of cell cycle progression in cervical cancer cells: Inhibition of Hedgehog/GLI signaling cascade.
PMID 36712982 | PMCID PMC9874127 | DOI 10.3389/fchem.2022.1064191 · Frontiers in chemistry · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GLI1 | “Moreover, CAR inhibited the HH/GLI signaling pathway by down regulating the expression of SMO, PTCH and GLI1 proteins in cervical carcinoma cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | prostate cancer | “Moreover, our previous reports have established that carvacrol (CAR) inhibited the proliferation of prostate cancer cells via inhibiting the Notch signaling pathway and thus, it was rational to explore its antiproliferative effects in cervical cancer cell lines.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CDK4 | “CAR efficiently inhibited the growth of cervical cancer cells via arresting the cell cycle at G0/G1 phase and modulated the gene expression of related proteins (p21, p27, cyclin D1 and CDK4).” | 0.98 | hgnc_dict_v1 |
| gene | SMO | “Moreover, CAR inhibited the HH/GLI signaling pathway by down regulating the expression of SMO, PTCH and GLI1 proteins in cervical carcinoma cells.” | 0.98 | hgnc_dict_v1 |
Moringa oleifera methanolic leaves extract induces apoptosis and G0/G1 cell cycle arrest via downregulation of Hedgehog Signaling Pathway in human prostate PC-3 cancer cells.
PMID 32588472 | DOI 10.1111/jfbc.13338 · Journal of food biochemistry · 2020 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GLI1 | “Decreased mRNA expression of GLI1 transcription factor and SMO protein of Hedgehog signaling pathway may be involved in antiproliferative effects of M. oleifera leaves extract against prostate cancer cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | prostate cancer | “The inadequacy of effective treatment approaches for prostate cancer enlightens the crucial necessity for the search and emergence of novel and multitasking anticancer substances.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SMO | “Decreased mRNA expression of GLI1 transcription factor and SMO protein of Hedgehog signaling pathway may be involved in antiproliferative effects of M. oleifera leaves extract against prostate cancer cells.” | 0.98 | hgnc_dict_v1 |