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GSK3B and Alzheimer disease are reported together in 2 articles.
Gene
GSK3B
- HGNC
- HGNC:4617
15articles
15mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Network pharmacology and molecular dynamic simulation integrated strategy for the screening of active components and mechanisms of phytochemicals from Datura innoxia on Alzheimer and cognitive decline.
PMID 38287491 | DOI 10.1080/07391102.2024.2308756 · Journal of biomolecular structure & dynamics · 2025 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GSK3B | “Based on the STRING and Cytoscape network-analysis platforms, the top ten anti-AD core targets include APP, CASP3, IL6, BACE1, IL1B, ACE, PSEN1, GAPDH, GSK3B and ACHE.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Alzheimer's disease (AD) ranks as the most prevalent neurodegenerative disorder with dementia and it accounts for more than 70% of all cases.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CASP3 | “Based on the STRING and Cytoscape network-analysis platforms, the top ten anti-AD core targets include APP, CASP3, IL6, BACE1, IL1B, ACE, PSEN1, GAPDH, GSK3B and ACHE.” | 0.98 | hgnc_dict_v1 |
| gene | BACE1 | “Based on the STRING and Cytoscape network-analysis platforms, the top ten anti-AD core targets include APP, CASP3, IL6, BACE1, IL1B, ACE, PSEN1, GAPDH, GSK3B and ACHE.” | 0.98 | hgnc_dict_v1 |
Therapeutic Potential of products derived from Pluchea lanceolata for Alzheimer's Disease Treatment.
PMID 40986212 | DOI 10.1007/s12031-025-02409-5 · Journal of molecular neuroscience : MN · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GSK3B | “Network pharmacology yielded 30 of such common targets of AD-neolupenol (e.g., GSK3B, CASP3, TNF, and BACE1), enriched in pathways such as amyloid processing, tau phosphorylation, oxidative stress response, and lipid metabolism (FDR-adjusted p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Therapeutic Potential of products derived from Pluchea lanceolata for Alzheimer's Disease Treatment.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CASP3 | “Network pharmacology yielded 30 of such common targets of AD-neolupenol (e.g., GSK3B, CASP3, TNF, and BACE1), enriched in pathways such as amyloid processing, tau phosphorylation, oxidative stress response, and lipid metabolism (FDR-adjusted p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| gene | BACE1 | “Network pharmacology yielded 30 of such common targets of AD-neolupenol (e.g., GSK3B, CASP3, TNF, and BACE1), enriched in pathways such as amyloid processing, tau phosphorylation, oxidative stress response, and lipid metabolism (FDR-adjusted p < 0.0001).” | 0.98 | hgnc_dict_v1 |