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GSTM1 and obesity are reported together in 3 articles.
Gene
GSTM1
- HGNC
- HGNC:4632
46articles
46mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
leukemia 7colorectal cancer 6diabetes mellitus 4hypertension 3obesity 3breast cancer 2asthma 1autism spectrum disorder 1
Reported variants (articles · ClinVar status)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Antioxidants-Related Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), and Nitric Oxide Synthase (NOS) Gene Variants Analysis in an Obese Population: A Preliminary Case-Control Study.
PMID 33924357 | PMCID PMC8070436 | DOI 10.3390/antiox10040595 · Antioxidants (Basel, Switzerland) · 2021 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GSTM1 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Oxidative stress and antioxidants play an important role in obesity etiopathology.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SOD1 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
| gene | SOD2 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
Association of glutathione S-transferase GSTM1 and GSTT1 deletion polymorphisms with obesity and their relationship with body mass index, lipoprotein and hypertension among young age Saudis.
PMID 27721975 | PMCID PMC5036254 | DOI 10.1177/2048004016669645 · JRSM cardiovascular disease · 2016 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GSTM1 | “Association of glutathione S-transferase GSTM1 and GSTT1 deletion polymorphisms with obesity and their relationship with body mass index, lipoprotein and hypertension among young age Saudis.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Association of glutathione S-transferase GSTM1 and GSTT1 deletion polymorphisms with obesity and their relationship with body mass index, lipoprotein and hypertension among young age Saudis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | GSTT1 | “Association of glutathione S-transferase GSTM1 and GSTT1 deletion polymorphisms with obesity and their relationship with body mass index, lipoprotein and hypertension among young age Saudis.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “Association of glutathione S-transferase GSTM1 and GSTT1 deletion polymorphisms with obesity and their relationship with body mass index, lipoprotein and hypertension among young age Saudis.” | 0.98 | phenotype_alias_lexicon_v2 |
T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking.
PMID 16620396 | PMCID PMC1458325 | DOI 10.1186/1471-2350-7-38 · BMC medical genetics · 2006 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | GSTM1 | “BACKGROUND: The association of the deletion in GSTT1 and GSTM1 genes with coronary artery disease (CAD) among smokers is controversial.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Univariate analysis also showed that smoking, age, hypercholesterolemia and hypertriglyceridemia, diabetes mellitus, family history of CAD, hypertension and obesity are all associated with CAD, whereas gender and myocardial infarction are not.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | GSTT1 | “BACKGROUND: The association of the deletion in GSTT1 and GSTM1 genes with coronary artery disease (CAD) among smokers is controversial.” | 0.98 | hgnc_dict_v1 |
| phenotype | myocardial infarction | “Univariate analysis also showed that smoking, age, hypercholesterolemia and hypertriglyceridemia, diabetes mellitus, family history of CAD, hypertension and obesity are all associated with CAD, whereas gender and myocardial infarction are not.” | 0.98 | phenotype_alias_lexicon_v2 |