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HFE and COVID-19 are reported together in 1 article.

Gene

HFE

HGNC
HGNC:4886
15articles
15mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 2hepatocellular carcinoma 2thalassemia 2COVID-19 1SARS 1cardiomyopathy 1
Reported variants (articles · ClinVar status)
H63D 6rs1800562 2p.C282Y 1p.H63D 1p.His63Asp 1rs1799945 1
HGNC ↗ClinVar ↗GeneCards ↗PubMed ↗
Phenotype

COVID-19

1,317articles
1,317mentions
12co-reported genes shown
Most co-reported genes (articles)
ACE2 81TMPRSS2 18ACE 8ABO 5HLA-B 5STAT1 5TLR4 5CRP 4HLA-A 4HLA-DRB1 4IRF7 4STAT2 4
MedGen ↗ClinVar ↗PubMed ↗

Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.

Publications

1 records shown · first 60

Whole-Exome Sequencing Detecting a Recurrent Pathogenic Mutation, HFE p.His63Asp (H63D) in COVID-19 Patients and Its Effect on Mortality.

PMID 39054721 | DOI 10.24976/Discov.Med.202436186.140 · Discovery medicine · 2024 · 15 validated mentions
View on PubMed ↗All extracted evidence
Evidence preview
TypeEntitySource evidenceConfidenceExtractor
geneHFE“Whole-Exome Sequencing Detecting a Recurrent Pathogenic Mutation, HFE p.His63Asp (H63D) in COVID-19 Patients and Its Effect on Mortality.”0.98hgnc_dict_v1
phenotypeCOVID-19“Whole-Exome Sequencing Detecting a Recurrent Pathogenic Mutation, HFE p.His63Asp (H63D) in COVID-19 Patients and Its Effect on Mortality.”0.98phenotype_alias_lexicon_v2
geneCFH“RESULTS: The study showed that the genetic variants associated with genes such as Homeostatic Iron Regulator (HFE) (found in 7 patients, representing 44%), complement factor H (CFH) (6 patients, 38%), cadherin 23 (CDH23) (4 patients, 25%), cytotoxic T-lymphocyte associated protein 4 (CTLA-4) (3 patients, 19%), Transforming Growth Factor Beta 1 (TGFB1) (3 patients, 19%), CREB-binding protein (CREBBP) (2 patients, 13%), E1A Binding Protein P300 (EP300) (2 patients, 13%), hemoglobin subunit beta (HBB) (2 patients, 13%), interferon regulatory factor 7 (IRF7) (2 patients, 13%), and unc-119 lipid binding chaperone (UNC119) (2 patients, 13%) might be associated with susceptibility to coronavirus.”0.98hgnc_dict_v1
geneCDH23“RESULTS: The study showed that the genetic variants associated with genes such as Homeostatic Iron Regulator (HFE) (found in 7 patients, representing 44%), complement factor H (CFH) (6 patients, 38%), cadherin 23 (CDH23) (4 patients, 25%), cytotoxic T-lymphocyte associated protein 4 (CTLA-4) (3 patients, 19%), Transforming Growth Factor Beta 1 (TGFB1) (3 patients, 19%), CREB-binding protein (CREBBP) (2 patients, 13%), E1A Binding Protein P300 (EP300) (2 patients, 13%), hemoglobin subunit beta (HBB) (2 patients, 13%), interferon regulatory factor 7 (IRF7) (2 patients, 13%), and unc-119 lipid binding chaperone (UNC119) (2 patients, 13%) might be associated with susceptibility to coronavirus.”0.98hgnc_dict_v1