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HLA-A and autism spectrum disorder are reported together in 1 article.
Gene
HLA-A
- HGNC
- HGNC:4931
59articles
59mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
COVID-19 4renal failure 2systemic lupus erythematosus 2MERS 1SARS 1autism spectrum disorder 1diabetes mellitus 1hepatitis C 1
Reported variants (articles · ClinVar status)
Phenotype
Autism spectrum disorder
- HPO
- HP:0000729
881articles
881mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case Control Study.
PMID 24672722 | PMCID PMC3929985 | DOI 10.1155/2014/242048 · Autism research and treatment · 2014 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-A | “In class I the HLA-A*01 (P = 0.03, OR 2.68), A*02 (P = 0.001, OR 3.02) and HLA-B*07 (P = 0.01, OR 3.27), were significantly associated with autism.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case Control Study.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HLA-B | “In class I the HLA-A*01 (P = 0.03, OR 2.68), A*02 (P = 0.001, OR 3.02) and HLA-B*07 (P = 0.01, OR 3.27), were significantly associated with autism.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “In this current study, we compared the HLA class I and class II alleles and haplotypes in 35 autistic children with 100 control subjects from Saudi Arabia, using PCR-SSP method and Luminex technology. While the four-loci genotype study showed that A*01-B*07-DRB1*0701-DQB1*0602 (P = 0.001, OR 41.9) and the A*31-B*51-DRB1*0103-DQB1*0302 (P = 0.012, OR 4.8) are positively associated with autism among Saudi patients.” | 0.95 | saudi_context_rules_v1 |