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HLA-A and renal failure are reported together in 2 articles.
Gene
HLA-A
- HGNC
- HGNC:4931
59articles
59mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
COVID-19 4renal failure 2systemic lupus erythematosus 2MERS 1SARS 1autism spectrum disorder 1diabetes mellitus 1hepatitis C 1
Reported variants (articles · ClinVar status)
Phenotype
Renal failure
523articles
523mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Identification of pathogenic genes associated with CKD: An integrated bioinformatics approach.
PMID 36035163 | PMCID PMC9403320 | DOI 10.3389/fgene.2022.891055 · Frontiers in genetics · 2022 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-A | “After sub-network analysis we identified six overlapped hub genes (RPS5, RPL37A, RPLP0, CXCL8, HLA-A, and ANXA1).” | 0.98 | hgnc_dict_v1 |
| phenotype | renal failure | “Identification of pathogenic genes associated with CKD: An integrated bioinformatics approach.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | RPS5 | “After sub-network analysis we identified six overlapped hub genes (RPS5, RPL37A, RPLP0, CXCL8, HLA-A, and ANXA1).” | 0.98 | hgnc_dict_v1 |
| gene | RPL37A | “After sub-network analysis we identified six overlapped hub genes (RPS5, RPL37A, RPLP0, CXCL8, HLA-A, and ANXA1).” | 0.98 | hgnc_dict_v1 |
HLA class I and class II associations with ESRD in Saudi Arabian population.
PMID 25380295 | PMCID PMC4224393 | DOI 10.1371/journal.pone.0111403 · PloS one · 2014 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-A | “The haplotypes positively associated with ESRD were: HLA-A*01-DRB1*13 and HLA-A*30-DRBI*03.” | 0.98 | hgnc_dict_v1 |
| phenotype | renal failure | “HLA class I and class II associations with ESRD in Saudi Arabian population.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HLA-B | “The alleles positively associated to the ESRD were: HLA-B*15, B*18, B*49 - DRB1*03, negatively associated alleles were A*26, HLA-B*39, B*50.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia | “HLA class I and class II associations with ESRD in Saudi Arabian population. Our interest was to evaluate the possible associations of HLA class I and class II antigens with ESRD independent of other factors, in Saudi Arabia population. METHODOLOGY: A retrospective study to determine the HLA class I and class II polymorphisms and their association with ESRD, was performed on 350 patients with ESRD, and 105 healthy unrelated control.” | 0.95 | saudi_context_rules_v1 |