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HLA-A and systemic lupus erythematosus are reported together in 2 articles.
Gene
HLA-A
- HGNC
- HGNC:4931
59articles
59mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
COVID-19 4renal failure 2systemic lupus erythematosus 2MERS 1SARS 1autism spectrum disorder 1diabetes mellitus 1hepatitis C 1
Reported variants (articles · ClinVar status)
Phenotype
Systemic lupus erythematosus
191articles
191mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Association Analysis of the MHC in Lupus Nephritis.
PMID 28754791 | PMCID PMC5661284 | DOI 10.1681/ASN.2016121331 · Journal of the American Society of Nephrology : JASN · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-A | “We discovered five independent risk variants for LN within the MHC region, including HLA-DRβ1 amino acid 11 (Pomnibus<0.001), HLA-DQβ1 amino acid 45 (P<0.001; odds ratio, 0.58; 95% confidence interval, 0.52 to 0.65), HLA-A amino acid 156 (Pomnibus<0.001), HLA-DPβ1 amino acid 76 (Pomnibus<0.001), and a missense variant in PRRC2A (rs114580964; P<0.001; odds ratio, 0.38; 95% confidence interval, 0.30 to 0.49) at genome-wide significance.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Association Analysis of the MHC in Lupus Nephritis.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | PRRC2A | “We discovered five independent risk variants for LN within the MHC region, including HLA-DRβ1 amino acid 11 (Pomnibus<0.001), HLA-DQβ1 amino acid 45 (P<0.001; odds ratio, 0.58; 95% confidence interval, 0.52 to 0.65), HLA-A amino acid 156 (Pomnibus<0.001), HLA-DPβ1 amino acid 76 (Pomnibus<0.001), and a missense variant in PRRC2A (rs114580964; P<0.001; odds ratio, 0.38; 95% confidence interval, 0.30 to 0.49) at genome-wide significance.” | 0.98 | hgnc_dict_v1 |
| variant | rs114580964 | “We discovered five independent risk variants for LN within the MHC region, including HLA-DRβ1 amino acid 11 (Pomnibus<0.001), HLA-DQβ1 amino acid 45 (P<0.001; odds ratio, 0.58; 95% confidence interval, 0.52 to 0.65), HLA-A amino acid 156 (Pomnibus<0.001), HLA-DPβ1 amino acid 76 (Pomnibus<0.001), and a missense variant in PRRC2A (rs114580964; P<0.001; odds ratio, 0.38; 95% confidence interval, 0.30 to 0.49) at genome-wide significance.” | 0.90 | hgvs_regex_v1 |
Association of HLA-DRB1*15 and HLADQB1*06 with SLE in Saudis.
PMID 23793423 | PMCID PMC6078530 | DOI 10.5144/0256-4947.2013.229 · Annals of Saudi medicine · 2013 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-A | “The aim of this study was to determine the association of HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1 with SLE susceptibility in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Association of HLA-DRB1*15 and HLADQB1*06 with SLE in Saudis.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HLA-DRB1 | “Association of HLA-DRB1*15 and HLADQB1*06 with SLE in Saudis.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The aim of this study was to determine the association of HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1 with SLE susceptibility in the Saudi population.” | 0.98 | hgnc_dict_v1 |