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HLA-B and hypertension are reported together in 2 articles.
Gene
HLA-B
- HGNC
- HGNC:4932
62articles
62mentions
5variants with confirmed gene link
Most co-reported phenotypes (articles)
COVID-19 5diabetes mellitus 4hypertension 2SARS 1autism spectrum disorder 1breast cancer 1cardiomyopathy 1celiac disease 1
Reported variants (articles · ClinVar status)
Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Whole-Exome Sequencing Reveals Rare Genetic Variants in Saudi COVID-19 Patients with Extreme Phenotypes.
PMID 41012626 | PMCID PMC12474163 | DOI 10.3390/v17091198 · Viruses · 2025 · 17 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-B | “The gene with the highest number of variants was HLA-DRB1, followed by HLA-B, ABO, HPS4, and SP110 displaying both common polymorphisms and rare variants.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “There was a substantial burden of comorbidity, including hypertension, ischemic heart disease, and T2DM, conditions which independently increase the risk of adverse outcomes in COVID-19 patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | INS | “The variants were further categorized by types to include single-nucleotide polymorphisms (SNPs), deletions (DEL), and insertions (INS).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “The gene with the highest number of variants was HLA-DRB1, followed by HLA-B, ABO, HPS4, and SP110 displaying both common polymorphisms and rare variants.” | 0.98 | hgnc_dict_v1 |
Association of HLA-B gene polymorphism and blood groups with COVID-19 susceptibility and severity.
PMID 40877359 | PMCID PMC12394550 | DOI 10.1038/s41598-025-15455-1 · Scientific reports · 2025 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-B | “Association of HLA-B gene polymorphism and blood groups with COVID-19 susceptibility and severity.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “A strong correlation was observed between co-morbidities (hypertension, diabetes) and severe COVID-19 outcomes.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ABO | “Among these, the HLA polymorphisms and ABO blood groups are known to influence the immune system.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Association of HLA-B gene polymorphism and blood groups with COVID-19 susceptibility and severity.” | 0.98 | phenotype_alias_lexicon_v2 |