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HLA-DQA1 and diabetes mellitus are reported together in 3 articles.
Gene
HLA-DQA1
- HGNC
- HGNC:4942
9articles
9mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 3celiac disease 2systemic lupus erythematosus 2hepatitis B 1hepatocellular carcinoma 1multiple sclerosis 1nephrotic syndrome 1rheumatoid arthritis 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Exploring the role of genetic variants in susceptibility to autoimmune Diseases: A molecular genetics approach.
PMID 41237580 | DOI 10.1016/j.humimm.2025.111614 · Human immunology · 2025 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQA1 | “This study identifies several significant genetic variants associated with autoimmune diseases, including PTPN22, HLA-DRB1, HLA-DQA1, IRF5, IL10, and other immune-regulatory genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “The purpose of this study is to identify key genetic variants associated with rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and type 1 diabetes, and to investigate how these variants interact with environmental exposures to influence risk and age of onset.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | PTPN22 | “This study identifies several significant genetic variants associated with autoimmune diseases, including PTPN22, HLA-DRB1, HLA-DQA1, IRF5, IL10, and other immune-regulatory genes.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “This study identifies several significant genetic variants associated with autoimmune diseases, including PTPN22, HLA-DRB1, HLA-DQA1, IRF5, IL10, and other immune-regulatory genes.” | 0.98 | hgnc_dict_v1 |
Single nucleotide polymorphism rs 2070874 at Interleukin-4 is associated with increased risk of type 1 diabetes mellitus independently of human leukocyte antigens.
PMID 35404688 | PMCID PMC9006359 | DOI 10.1177/03946320221090330 · International journal of immunopathology and pharmacology · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQA1 | “METHODS: Accordingly, we compared frequencies of five different single nucleotide polymorphisms (SNPs) in T1DM patients and healthy controls who had been typed for HLA-DRB1, HLA-DQA1, and HLA-DQB1 genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Single nucleotide polymorphism rs 2070874 at Interleukin-4 is associated with increased risk of type 1 diabetes mellitus independently of human leukocyte antigens.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | HLA-DRB1 | “METHODS: Accordingly, we compared frequencies of five different single nucleotide polymorphisms (SNPs) in T1DM patients and healthy controls who had been typed for HLA-DRB1, HLA-DQA1, and HLA-DQB1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “METHODS: Accordingly, we compared frequencies of five different single nucleotide polymorphisms (SNPs) in T1DM patients and healthy controls who had been typed for HLA-DRB1, HLA-DQA1, and HLA-DQB1 genes.” | 0.98 | hgnc_dict_v1 |
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
PMID 28566273 | PMCID PMC5652602 | DOI 10.2337/db16-1253 · Diabetes · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQA1 | “We identified 13 novel T2D-associated loci (P < 5 × 10-8), including variants near the GLP2R, GIP, and HLA-DQA1 genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | GLP2R | “We identified 13 novel T2D-associated loci (P < 5 × 10-8), including variants near the GLP2R, GIP, and HLA-DQA1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | GIP | “We identified 13 novel T2D-associated loci (P < 5 × 10-8), including variants near the GLP2R, GIP, and HLA-DQA1 genes.” | 0.98 | hgnc_dict_v1 |