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HLA-DQB1 and diabetes mellitus are reported together in 7 articles.
Gene
HLA-DQB1
- HGNC
- HGNC:4944
40articles
40mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 7celiac disease 3COVID-19 2systemic lupus erythematosus 2MERS 1asthma 1multiple sclerosis 1nephrotic syndrome 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
7 records shown · first 60Identification of novel genomic variants in diabetic nephropathy patients using whole-exome sequencing: a pilot investigation.
PMID 41970998 | PMCID PMC13062162 | DOI 10.3389/fendo.2026.1798640 · Frontiers in endocrinology · 2026 · 15 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQB1 | “The shared genes, INSR, HLA-DQB1, and CRHR1, exhibited possible associations with T2D and DN, positioning them as key candidates for DN.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “BACKGROUND: Type 2 diabetes (T2D) is a challenge for the healthcare system.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | THADA | “RESULTS: The genes THADA, NOTCH4, and TNXB met the genome-wide threshold and showed minimal T2D association.” | 0.98 | hgnc_dict_v1 |
| gene | NOTCH4 | “RESULTS: The genes THADA, NOTCH4, and TNXB met the genome-wide threshold and showed minimal T2D association.” | 0.98 | hgnc_dict_v1 |
Autoimmune diabetes mellitus after COVID-19 vaccination in adult population: a systematic review of case reports.
PMID 37542216 | PMCID PMC10403898 | DOI 10.1186/s12902-023-01424-0 · BMC endocrine disorders · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQB1 | “Five patients (41.7%) had genetic susceptibility, with RNA binding motif protein 45 (RBM45/DRB1) and major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) mutations being prominent.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Autoimmune diabetes mellitus after COVID-19 vaccination in adult population: a systematic review of case reports.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | RBM45 | “Five patients (41.7%) had genetic susceptibility, with RNA binding motif protein 45 (RBM45/DRB1) and major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) mutations being prominent.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Autoimmune diabetes mellitus after COVID-19 vaccination in adult population: a systematic review of case reports.” | 0.98 | phenotype_alias_lexicon_v2 |
Decoding Diabetes Biomarkers and Related Molecular Mechanisms by Using Machine Learning, Text Mining, and Gene Expression Analysis.
PMID 36360783 | PMCID PMC9656783 | DOI 10.3390/ijerph192113890 · International journal of environmental research and public health · 2022 · 21 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQB1 | “Machine learning algorithms highlighted the use of the HLA-DQB1 gene as a biomarker for diabetes early detection.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Decoding Diabetes Biomarkers and Related Molecular Mechanisms by Using Machine Learning, Text Mining, and Gene Expression Analysis.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HNF4A | “Among these genes, HNF4A, PPARA, VEGFA, TCF7L2, HLA-DRB1, PPARG, NOS3, KCNJ11, PRKAA2, and HNF1A were mentioned in more than 200 articles.” | 0.98 | hgnc_dict_v1 |
| gene | PPARA | “Among these genes, HNF4A, PPARA, VEGFA, TCF7L2, HLA-DRB1, PPARG, NOS3, KCNJ11, PRKAA2, and HNF1A were mentioned in more than 200 articles.” | 0.98 | hgnc_dict_v1 |
Single nucleotide polymorphism rs 2070874 at Interleukin-4 is associated with increased risk of type 1 diabetes mellitus independently of human leukocyte antigens.
PMID 35404688 | PMCID PMC9006359 | DOI 10.1177/03946320221090330 · International journal of immunopathology and pharmacology · 2022 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQB1 | “METHODS: Accordingly, we compared frequencies of five different single nucleotide polymorphisms (SNPs) in T1DM patients and healthy controls who had been typed for HLA-DRB1, HLA-DQA1, and HLA-DQB1 genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Single nucleotide polymorphism rs 2070874 at Interleukin-4 is associated with increased risk of type 1 diabetes mellitus independently of human leukocyte antigens.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | HLA-DRB1 | “METHODS: Accordingly, we compared frequencies of five different single nucleotide polymorphisms (SNPs) in T1DM patients and healthy controls who had been typed for HLA-DRB1, HLA-DQA1, and HLA-DQB1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQA1 | “METHODS: Accordingly, we compared frequencies of five different single nucleotide polymorphisms (SNPs) in T1DM patients and healthy controls who had been typed for HLA-DRB1, HLA-DQA1, and HLA-DQB1 genes.” | 0.98 | hgnc_dict_v1 |
Role of HLA-DQ typing and antitissue transglutaminase antibody titres in diagnosing coeliac disease among Sudanese children with type 1 diabetes mellitus.
PMID 35074908 | PMCID PMC8788197 | DOI 10.1136/bmjgast-2021-000735 · BMJ open gastroenterology · 2022 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQB1 | “Additionally, PCR-based analysis of Major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) genotyping was implemented in three study population groups as follows: group 1 (n=25) (+ve DM1 and +ve CD), group 2 (n=63) (-ve DM1 and +ve CD) and control group 3 (n=2) (+ve CD).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Role of HLA-DQ typing and antitissue transglutaminase antibody titres in diagnosing coeliac disease among Sudanese children with type 1 diabetes mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | celiac disease | “Role of HLA-DQ typing and antitissue transglutaminase antibody titres in diagnosing coeliac disease among Sudanese children with type 1 diabetes mellitus.” | 0.93 | phenotype_alias_lexicon_v2 |
Association of serum 25-hydroxyvitamin D concentration with HLA-B, -DRB1 and -DQB1 genetic polymorphisms.
PMID 27623983 | DOI 10.1038/ejcn.2016.160 · European journal of clinical nutrition · 2017 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQB1 | “SUBJECTS/METHODS: HLA-B (n=395), HLA-DRB1 (n=501) and HLA-DQB1 (n=475) alleles were genotyped in pregnant women (mothers of children who later developed type 1 diabetes and mothers of non-diabetic children).” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “BACKGROUND/OBJECTIVES: The human leukocyte antigen (HLA) gene region associates with the risk for several autoimmune diseases, including type 1 diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HLA-B | “Association of serum 25-hydroxyvitamin D concentration with HLA-B, -DRB1 and -DQB1 genetic polymorphisms.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DRB1 | “SUBJECTS/METHODS: HLA-B (n=395), HLA-DRB1 (n=501) and HLA-DQB1 (n=475) alleles were genotyped in pregnant women (mothers of children who later developed type 1 diabetes and mothers of non-diabetic children).” | 0.98 | hgnc_dict_v1 |
Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes.
PMID 20858521 | DOI 10.1016/j.humimm.2010.09.008 · Human immunology · 2010 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQB1 | “In conclusion, these results show a strong association of HLA-DQB1*0201/0302 and DRB1*03/04 with T1DM.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Riyadh | “Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes. The objective of this study was to examine diabetic auto-antibodies (ICA-512, GAD65) and the HLA-DR/DQ genotype among T1DM Saudi children in a cross-sectional study conducted at King Khalid University and National Guard Hospitals, Riyadh. Subjects included in this study were 103 Saudi patients and 180 healthy controls. Thus, combining genetic markers with autoantibody is useful in a screening program for early detection of T1DM among Saudi children.” | 0.95 | saudi_context_rules_v1 |