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HLA-DRB1 and leukemia are reported together in 2 articles.
Gene
HLA-DRB1
- HGNC
- HGNC:4948
61articles
61mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Number of HLA-Mismatched Eplets Is Not Associated with Major Outcomes in Haploidentical Transplantation with Post-Transplantation Cyclophosphamide: A Center for International Blood and Marrow Transplant Research Study.
PMID 34774819 | PMCID PMC8848305 | DOI 10.1016/j.jtct.2021.11.001 · Transplantation and cellular therapy · 2022 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DRB1 | “This was likely attributable to ME load at the HLA-DRB1 locus, which was similarly associated with slower neutrophil engraftment (HR, 0.82; 95% CI, 0.73 to 0.92; P = .001) and slower platelet engraftment (HR, 0.76; 95% CI, 0.70 to 0.84; P < .0001).” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “We analyzed data from 1287 patients who underwent their first haplo-HSCT for acute lymphoblastic leukemia, acute myelogenous leukemia, or myelodysplastic syndrome between 2013 and 2017, as entered in the Center for International Blood and Marrow Transplant Research database.” | 0.98 | phenotype_alias_lexicon_v2 |
The Wilms' tumor antigen is a novel target for human CD4+ regulatory T cells: implications for immunotherapy.
PMID 18676860 | DOI 10.1158/0008-5472.CAN-08-0050 · Cancer research · 2008 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DRB1 | “We have generated T-cell lines and clones that specifically recognized a WT1-84 (RYFKLSHLQMHSRKH) peptide in an HLA-DRB1*0402-restricted manner.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “The Wilms' tumor antigen (WT1) is overexpressed in several human leukemias and thus considered as promising target for development of leukemia vaccine.” | 0.98 | phenotype_alias_lexicon_v2 |