Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
HLA-DRB1 and systemic lupus erythematosus are reported together in 5 articles.
Gene
HLA-DRB1
- HGNC
- HGNC:4948
61articles
61mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Systemic lupus erythematosus
191articles
191mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
5 records shown · first 60The expression of pruritus-associated genes in seven skin diseases: Evidence from microarray.
PMID 41081460 | DOI 10.1111/jdv.70109 · Journal of the European Academy of Dermatology and Venereology : JEADV · 2026 · 18 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DRB1 | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “BACKGROUND: Pruritus may accompany different skin diseases including atopic dermatitis, lichen planus, psoriasis, cutaneous lupus erythematosus, acne, alopecia areata and rosacea.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CLEC7A | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |
| gene | IL7R | “We found the top differentially upregulated pruritus-associated genes were CLEC7A, IL7R and TNFRSF1B in acne; HLA-DRA, IL2RG and POU2AF1 in alopecia areata; IL2RG, PLEC and CTLA4 in atopic dermatitis; CLEC7A, IL7R and LIPA in cutaneous lupus erythematosus; HLA-DRA, ABCA12 and IL7R in lichen planus; CLEC7A, TGM1 and SDR9C7 in psoriasis and IL7R, HLA-DRB1/HLA-DRB3/HLA-DRB4/HLA-DRB5/LOC105369230 and POU2AF1 in rosacea.” | 0.98 | hgnc_dict_v1 |
Exploring the role of genetic variants in susceptibility to autoimmune Diseases: A molecular genetics approach.
PMID 41237580 | DOI 10.1016/j.humimm.2025.111614 · Human immunology · 2025 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DRB1 | “This study identifies several significant genetic variants associated with autoimmune diseases, including PTPN22, HLA-DRB1, HLA-DQA1, IRF5, IL10, and other immune-regulatory genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “The purpose of this study is to identify key genetic variants associated with rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and type 1 diabetes, and to investigate how these variants interact with environmental exposures to influence risk and age of onset.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTPN22 | “This study identifies several significant genetic variants associated with autoimmune diseases, including PTPN22, HLA-DRB1, HLA-DQA1, IRF5, IL10, and other immune-regulatory genes.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQA1 | “This study identifies several significant genetic variants associated with autoimmune diseases, including PTPN22, HLA-DRB1, HLA-DQA1, IRF5, IL10, and other immune-regulatory genes.” | 0.98 | hgnc_dict_v1 |
Relation between HLA typing and clinical presentations in Systemic Lupus Erythematosus patients in Al-Qassim region, Saudi Arabia.
PMID 25246883 | PMCID PMC4166988 | DOI 10.12816/0006082 · International journal of health sciences · 2014 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DRB1 | “AIMS: This study was carried out to investigate, the association of HLA-DRB1, DRB3, DRB4, DRB5, and DQB1 alleles in SLE patients and clinical presentations at Qassim, Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Relation between HLA typing and clinical presentations in Systemic Lupus Erythematosus patients in Al-Qassim region, Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia, Qassim | “Relation between HLA typing and clinical presentations in Systemic Lupus Erythematosus patients in Al-Qassim region, Saudi Arabia. AIMS: This study was carried out to investigate, the association of HLA-DRB1, DRB3, DRB4, DRB5, and DQB1 alleles in SLE patients and clinical presentations at Qassim, Saudi Arabia. RESULTS: It was found that DRB3 is a protective gene among Saudi's against SLE, HLA DRB3, HLA DRB1*11 frequency was increased in patients with serositis with a p value of (0.004), (0.047) respectively, increased frequency of HLA DQB1*3 among SLE patients with skin manifestations with a p value of (0.041), the frequency of HLA DRB1*15 alleles was increased among SLE patients with nephritis with a p value of (0.029), the frequency of HLA DRB1*11 among those with hematological manifestations with a p value of (0.03) and the frequency DRB1*10 was found to be increased among SLE patients with neurological manifestations with a p value of (0.002). CONCLUSION: In contradistinction to what have been found among other populations DRB3 is a protective gene among Saudi's against SLE.” | 0.95 | saudi_context_rules_v1 |
Association of HLA-DRB1*15 and HLADQB1*06 with SLE in Saudis.
PMID 23793423 | PMCID PMC6078530 | DOI 10.5144/0256-4947.2013.229 · Annals of Saudi medicine · 2013 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DRB1 | “Association of HLA-DRB1*15 and HLADQB1*06 with SLE in Saudis.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “Association of HLA-DRB1*15 and HLADQB1*06 with SLE in Saudis.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HLA-A | “The aim of this study was to determine the association of HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1 with SLE susceptibility in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The aim of this study was to determine the association of HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1 with SLE susceptibility in the Saudi population.” | 0.98 | hgnc_dict_v1 |
The involvement of HLA -DRB1*, DQA1*, DQB1* and complement C4A loci in diagnosing systemic lupus erythematosus among Tunisians.
PMID 15310011 | PMCID PMC6147822 | DOI 10.5144/0256-4947.2004.31 · Annals of Saudi medicine · 2004 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DRB1 | “PATIENTS AND METHODS: We compared HLA-DRB1*, DQA1, DQB1* and C4 allotypes in 62 Tunisian SLE patients and 100 matched controls.” | 0.98 | hgnc_dict_v1 |
| phenotype | systemic lupus erythematosus | “The involvement of HLA -DRB1*, DQA1*, DQB1* and complement C4A loci in diagnosing systemic lupus erythematosus among Tunisians.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | C4A | “The involvement of HLA -DRB1*, DQA1*, DQB1* and complement C4A loci in diagnosing systemic lupus erythematosus among Tunisians.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQA1 | “HLA-DQA1*0102 and DQA1*0501 were significantly increased in the SLE patients.” | 0.98 | hgnc_dict_v1 |