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HMGB1 and SARS are reported together in 1 article.
Gene
HMGB1
- HGNC
- HGNC:4983
39articles
39mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 6inflammatory bowel disease 4epilepsy 3myocardial infarction 2ulcerative colitis 2COVID-19 1SARS 1arrhythmia 1
Reported variants (articles · ClinVar status)
Phenotype
SARS
347articles
347mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Cytokine Profiling among Children with Multisystem Inflammatory Syndrome versus Simple COVID-19 Infection: A Study from Northwest Saudi Arabia.
PMID 36101327 | PMCID PMC9312182 | DOI 10.3390/biology11070946 · Biology · 2022 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HMGB1 | “High cytokine levels (IL-1β, IL-6, IFN-α, GM-CSF, and HMGB1) were observed acutely in the MIS-C children, and a persistent elevation of some cytokines were reported at midterm follow-up, especially in Group B.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “BACKGROUND: Multisystem Inflammatory Syndrome in Children (MIS-C) is a novel syndrome associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with varying clinical features.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | COVID-19 | “Cytokine Profiling among Children with Multisystem Inflammatory Syndrome versus Simple COVID-19 Infection: A Study from Northwest Saudi Arabia.” | 0.98 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Cytokine Profiling among Children with Multisystem Inflammatory Syndrome versus Simple COVID-19 Infection: A Study from Northwest Saudi Arabia. RESULTS: We identified 60 children with MIS-C (mean age of 7.4 ± 3.8 years) compared to 30 age- and sex-matched controls with simple COVID-19.” | 0.95 | saudi_context_rules_v1 |