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HMGB1 and arrhythmia are reported together in 1 article.
Gene
HMGB1
- HGNC
- HGNC:4983
39articles
39mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
diabetes mellitus 6inflammatory bowel disease 4epilepsy 3myocardial infarction 2ulcerative colitis 2COVID-19 1SARS 1arrhythmia 1
Reported variants (articles · ClinVar status)
Phenotype
Arrhythmia
555articles
555mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Pharmacotherapeutic potential of artemetin against amiodarone instigated sub-chronic hepatotoxicity via modulating TLR4/HMGB1/RAGE and NF-κB signaling pathways: An in-vivo and in-silico approach.
PMID 40582623 | DOI 10.1016/j.toxicon.2025.108471 · Toxicon : official journal of the International Society on Toxinology · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HMGB1 | “Pharmacotherapeutic potential of artemetin against amiodarone instigated sub-chronic hepatotoxicity via modulating TLR4/HMGB1/RAGE and NF-κB signaling pathways: An in-vivo and in-silico approach.” | 0.98 | hgnc_dict_v1 |
| phenotype | arrhythmia | “Amiodarone (AMI) has been widely used in cardiac patients to prevent the onset of life-threating cardiac arrhythmias.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “Pharmacotherapeutic potential of artemetin against amiodarone instigated sub-chronic hepatotoxicity via modulating TLR4/HMGB1/RAGE and NF-κB signaling pathways: An in-vivo and in-silico approach.” | 0.98 | hgnc_dict_v1 |