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HMGB1 and inflammatory bowel disease are reported together in 4 articles.

Gene

HMGB1

39articles

39mentions

1variants with confirmed gene link

Most co-reported phenotypes (articles)

Reported variants (articles · ClinVar status)

Phenotype

693articles

693mentions

12co-reported genes shown

Most co-reported genes (articles)

Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.

4 records shown · first 60

PMID 40606616 | PMCID PMC12213710 | DOI 10.3389/fphar.2025.1546010 · Frontiers in pharmacology · 2025 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	HMGB1	“Treatment resulted in substantial reductions in key inflammatory markers, including HMGB1, RAGE, TLR4 expression, NFκB activity, pro-inflammatory cytokines (TNF-α and IL-6), and apoptosis marker caspase-3.”	0.98	hgnc_dict_v1
phenotype	inflammatory bowel disease	“The goal was to protect RSV-CSNPs from degradation in the acidic gastric environment and facilitate targeted sustained release in the colon to address inflammatory bowel disease.”	0.98	phenotype_alias_lexicon_v2
gene	TLR4	“Treatment resulted in substantial reductions in key inflammatory markers, including HMGB1, RAGE, TLR4 expression, NFκB activity, pro-inflammatory cytokines (TNF-α and IL-6), and apoptosis marker caspase-3.”	0.98	hgnc_dict_v1
phenotype	ulcerative colitis	“These nanoparticles represent a promising strategy for effectively managing ulcerative colitis and related inflammatory bowel diseases.”	0.98	phenotype_alias_lexicon_v2

PMID 39119265 | PMCID PMC11303854 | DOI 10.1093/toxres/tfae108 · Toxicology research · 2024 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	HMGB1	“Rutin is a natural flavonoid with many pharmacological activities and its role in acetic acid-induced ulcerative colitis through the high mobility group B1 (HMGB1)/ toll-like receptor-4 (TLR4)/ myeloid differentiation primary response protein 88 (MYD88)/ nuclear factor-kB (NF-kB) signaling pathway needs to be explored.”	0.98	hgnc_dict_v1
phenotype	inflammatory bowel disease	“BACKGROUND: Ulcerative colitis, an inflammatory bowel disease, is characterized by a status of oxidative stress and inflammation.”	0.98	phenotype_alias_lexicon_v2
gene	TLR4	“Rutin is a natural flavonoid with many pharmacological activities and its role in acetic acid-induced ulcerative colitis through the high mobility group B1 (HMGB1)/ toll-like receptor-4 (TLR4)/ myeloid differentiation primary response protein 88 (MYD88)/ nuclear factor-kB (NF-kB) signaling pathway needs to be explored.”	0.98	hgnc_dict_v1
gene	MYD88	“Rutin is a natural flavonoid with many pharmacological activities and its role in acetic acid-induced ulcerative colitis through the high mobility group B1 (HMGB1)/ toll-like receptor-4 (TLR4)/ myeloid differentiation primary response protein 88 (MYD88)/ nuclear factor-kB (NF-kB) signaling pathway needs to be explored.”	0.98	hgnc_dict_v1

PMID 33667522 | DOI 10.1016/j.lfs.2021.119295 · Life sciences · 2021 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	HMGB1	“Notably, no former studies have linked JAK2/STAT3, HMGB1/NF-κB, and Nrf2/HO-1 signaling in TNBS-evoked colitis.”	0.98	hgnc_dict_v1
phenotype	inflammatory bowel disease	“Linagliptin mitigates experimental inflammatory bowel disease in rats by targeting inflammatory and redox signaling.”	0.98	phenotype_alias_lexicon_v2
gene	JAK2	“Notably, no former studies have linked JAK2/STAT3, HMGB1/NF-κB, and Nrf2/HO-1 signaling in TNBS-evoked colitis.”	0.98	hgnc_dict_v1
gene	STAT3	“Notably, no former studies have linked JAK2/STAT3, HMGB1/NF-κB, and Nrf2/HO-1 signaling in TNBS-evoked colitis.”	0.98	hgnc_dict_v1

PMID 33412153 | DOI 10.1016/j.cbi.2021.109368 · Chemico-biological interactions · 2021 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	HMGB1	“Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways.”	0.98	hgnc_dict_v1
phenotype	inflammatory bowel disease	“Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways.”	0.98	phenotype_alias_lexicon_v2
gene	SQSTM1	“More important, dapagliflozin enhanced colonic autophagy via upregulating Beclin 1 and downregulating p62 SQSTM1 protein expression.”	0.98	hgnc_dict_v1
phenotype	myocardial infarction	“Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has featured marked anti-inflammatory effects in murine models of myocardial infarction, renal injury, and neuroinflammation.”	0.98	phenotype_alias_lexicon_v2