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HSP90AA1 and Alzheimer disease are reported together in 4 articles.
Gene
HSP90AA1
- HGNC
- HGNC:5253
21articles
21mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Multi-target therapeutic potential of Neem (Azadirachta indica) phytochemicals in Alzheimer's disease: an integrative network pharmacology and molecular dynamics simulation approach.
PMID 41113166 | PMCID PMC12534210 | DOI 10.1007/s40203-025-00434-1 · In silico pharmacology · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HSP90AA1 | “Network analysis highlighted ESR1, HSP90AA1, SRC, HIF1A and EP300 as key hub genes within the AD-related compound-target network, suggesting critical regulatory roles.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Multi-target therapeutic potential of Neem (Azadirachta indica) phytochemicals in Alzheimer's disease: an integrative network pharmacology and molecular dynamics simulation approach.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | ESR1 | “Network analysis highlighted ESR1, HSP90AA1, SRC, HIF1A and EP300 as key hub genes within the AD-related compound-target network, suggesting critical regulatory roles.” | 0.98 | hgnc_dict_v1 |
| gene | SRC | “Network analysis highlighted ESR1, HSP90AA1, SRC, HIF1A and EP300 as key hub genes within the AD-related compound-target network, suggesting critical regulatory roles.” | 0.98 | hgnc_dict_v1 |
Network pharmacology and molecular simulations reveal multi-target neuroprotective potential of Rhamnolipid and Surfactin against Alzheimer's disease.
PMID 41207328 | DOI 10.1016/j.brainresbull.2025.111613 · Brain research bulletin · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HSP90AA1 | “RESULTS: Network pharmacology recognized 87 overlapping targets of Rhamnolipid and Surfactin with Alzheimer's disease, with hub genes involving CASP3, SRC, CTNNB1, HSP90AA1 and STAT3.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Network pharmacology and molecular simulations reveal multi-target neuroprotective potential of Rhamnolipid and Surfactin against Alzheimer's disease.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CASP3 | “RESULTS: Network pharmacology recognized 87 overlapping targets of Rhamnolipid and Surfactin with Alzheimer's disease, with hub genes involving CASP3, SRC, CTNNB1, HSP90AA1 and STAT3.” | 0.98 | hgnc_dict_v1 |
| gene | SRC | “RESULTS: Network pharmacology recognized 87 overlapping targets of Rhamnolipid and Surfactin with Alzheimer's disease, with hub genes involving CASP3, SRC, CTNNB1, HSP90AA1 and STAT3.” | 0.98 | hgnc_dict_v1 |
Network Theoretical Approach to Explore Factors Affecting Signal Propagation and Stability in Dementia's Protein-Protein Interaction Network.
PMID 35327643 | PMCID PMC8946103 | DOI 10.3390/biom12030451 · Biomolecules · 2022 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HSP90AA1 | “Using a clustering algorithm (Louvain method of modularity maximization) iteratively, we found a number of communities at different levels of hierarchy in PDN consisting of 95 "motif-localized hubs", out of which, 7 were present at deepest level and hence were key regulators (KRs) of PDN (HSP90AA1, HSP90AB1, EGFR, FYN, JUN, CELF2 and CTNNA3).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Though multiple research studies have analyzed disorders such as Alzheimer's disease and Frontotemporal dementia using a systems biology approach, a similar approach to dementia syndrome as a whole is required.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HSP90AB1 | “Using a clustering algorithm (Louvain method of modularity maximization) iteratively, we found a number of communities at different levels of hierarchy in PDN consisting of 95 "motif-localized hubs", out of which, 7 were present at deepest level and hence were key regulators (KRs) of PDN (HSP90AA1, HSP90AB1, EGFR, FYN, JUN, CELF2 and CTNNA3).” | 0.98 | hgnc_dict_v1 |
| gene | EGFR | “Using a clustering algorithm (Louvain method of modularity maximization) iteratively, we found a number of communities at different levels of hierarchy in PDN consisting of 95 "motif-localized hubs", out of which, 7 were present at deepest level and hence were key regulators (KRs) of PDN (HSP90AA1, HSP90AB1, EGFR, FYN, JUN, CELF2 and CTNNA3).” | 0.98 | hgnc_dict_v1 |
Integrated Left Ventricular Global Transcriptome and Proteome Profiling in Human End-Stage Dilated Cardiomyopathy.
PMID 27711126 | PMCID PMC5053516 | DOI 10.1371/journal.pone.0162669 · PloS one · 2016 · 19 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HSP90AA1 | “Among the most significantly upregulated (>5-fold) proteins were GRK5, APOA2, IGHG3, ANXA6, HSP90AA1, and ATP5C1 (p< 0.01).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Gene ontology analyses of DEGs and DEPs revealed significant overlap with enrichment of genes/proteins related to metabolic process, biosynthetic process, cellular component organization, oxidative phosphorylation, alterations in glycolysis and ATP synthesis, Alzheimer's disease, chemokine-mediated inflammation and cytokine signalling pathways.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | GRK5 | “Among the most significantly upregulated (>5-fold) proteins were GRK5, APOA2, IGHG3, ANXA6, HSP90AA1, and ATP5C1 (p< 0.01).” | 0.98 | hgnc_dict_v1 |
| gene | APOA2 | “Among the most significantly upregulated (>5-fold) proteins were GRK5, APOA2, IGHG3, ANXA6, HSP90AA1, and ATP5C1 (p< 0.01).” | 0.98 | hgnc_dict_v1 |