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HSP90AA1 and hypertension are reported together in 2 articles.
Gene
HSP90AA1
- HGNC
- HGNC:5253
21articles
21mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Network pharmacology and molecular docking: combined computational approaches to explore the antihypertensive potential of Fabaceae species.
PMID 38767701 | PMCID PMC11106056 | DOI 10.1186/s40643-024-00764-6 · Bioresources and bioprocessing · 2024 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HSP90AA1 | “Top hub genes identified were TLR4, MMP9, MAPK14, AKT1, VEGFA and HSP90AA1 with their respective associates.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “Hypertension is a major global public health issue, affecting quarter of adults worldwide.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “Top hub genes identified were TLR4, MMP9, MAPK14, AKT1, VEGFA and HSP90AA1 with their respective associates.” | 0.98 | hgnc_dict_v1 |
| gene | MMP9 | “Top hub genes identified were TLR4, MMP9, MAPK14, AKT1, VEGFA and HSP90AA1 with their respective associates.” | 0.98 | hgnc_dict_v1 |
Systematic elucidation of the multi-target pharmacological mechanism of Terminalia arjuna against congestive cardiac failure via network pharmacology and molecular modelling approaches.
PMID 37665010 | DOI 10.1080/14786419.2023.2252565 · Natural product research · 2023 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HSP90AA1 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that oleanolic acid, arjunolic acid, luteolin, kaempferol, cholesterol, ellagic acid 4-O-xylopyranoside 3,3'-dimethyl ether, and cyclohexyl (2,4-dimethyl phenyl) methanone contributed significantly to the development of CCF by affecting AKT1, MAPK14, TNF, IL6, ESR1, and HSP90AA1 genes.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “T. arjuna is being used in various regions for anginal pain, hypertension, congestive heart failure, and dyslipidemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | AKT1 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that oleanolic acid, arjunolic acid, luteolin, kaempferol, cholesterol, ellagic acid 4-O-xylopyranoside 3,3'-dimethyl ether, and cyclohexyl (2,4-dimethyl phenyl) methanone contributed significantly to the development of CCF by affecting AKT1, MAPK14, TNF, IL6, ESR1, and HSP90AA1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | MAPK14 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that oleanolic acid, arjunolic acid, luteolin, kaempferol, cholesterol, ellagic acid 4-O-xylopyranoside 3,3'-dimethyl ether, and cyclohexyl (2,4-dimethyl phenyl) methanone contributed significantly to the development of CCF by affecting AKT1, MAPK14, TNF, IL6, ESR1, and HSP90AA1 genes.” | 0.98 | hgnc_dict_v1 |