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IDH1 and thyroid cancer are reported together in 2 articles.
Gene
IDH1
- HGNC
- HGNC:5382
41articles
41mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
leukemia 13breast cancer 4colorectal cancer 4gastric cancer 2lymphoma 2thyroid cancer 2Down syndrome 1Klinefelter syndrome 1
Reported variants (articles · ClinVar status)
Phenotype
Thyroid cancer
216articles
216mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.
PMID 34997121 | PMCID PMC8741954 | DOI 10.1038/s41598-021-04214-7 · Scientific reports · 2022 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IDH1 | “Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.” | 0.98 | hgnc_dict_v1 |
| phenotype | thyroid cancer | “Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are oncogenic drivers to a variable extent in several tumors, including gliomas, acute myeloid leukemia (AML), cholangiocarcinoma, melanoma, and thyroid carcinoma.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | IDH2 | “Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models.” | 0.98 | hgnc_dict_v1 |
| gene | PRSS23 | “Among differentially expressed genes (DEGs), serine protease 23 (PRSS23) was upregulated in four datasets, i.e., in human colon carcinoma cells, mouse heart tissue, mouse neural stem cells, and human glioma cells.” | 0.98 | hgnc_dict_v1 |
Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers.
PMID 34462665 | PMCID PMC8375036 | DOI 10.3892/mco.2021.2373 · Molecular and clinical oncology · 2021 · 9 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IDH1 | “Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers.” | 0.98 | hgnc_dict_v1 |
| phenotype | thyroid cancer | “Conversely, analyses of 117 aggressive thyroid cancers [84, poorly differentiated thyroid cancer (PDTC); 33, anaplastic thyroid cancer (ATC)] from the Memorial Sloan Kettering Cancer Center cohort revealed ALK mutations in 3% of ATCs and fusions in 3.6% of PDTCs.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ALK | “Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers.” | 0.98 | hgnc_dict_v1 |
| gene | IDH2 | “Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers.” | 0.98 | hgnc_dict_v1 |