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IFI16 and autism spectrum disorder are reported together in 2 articles.
Gene
IFI16
- HGNC
- HGNC:5395
6articles
6mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Autism spectrum disorder
- HPO
- HP:0000729
881articles
881mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Association of social and cognitive impairment and biomarkers in autism spectrum disorders.
PMID 24400970 | PMCID PMC3896747 | DOI 10.1186/1742-2094-11-4 · Journal of neuroinflammation · 2014 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IFI16 | “This study aims to test the possible association between impaired levels of gamma aminobutyric acid (GABA), serotonin, dopamine, oxytocin, and interferon-γ-induced protein-16 (IFI16) and the severity of social and cognitive dysfunctions in individuals with autism spectrum disorders.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “Association of social and cognitive impairment and biomarkers in autism spectrum disorders.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | intellectual disability | “Association of social and cognitive impairment and biomarkers in autism spectrum disorders.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “MATERIALS AND METHODS: GABA, serotonin, dopamine, oxytocin, and IFI16 as biochemical parameters related to neurochemistry and inflammation were determined in the plasma of 52 Saudi autistic male patients, categorized as mild-moderate and severe as indicated by their Childhood Autism Rating Scale (CARS) or social responsiveness scale (SRS), and compared to 30 age- and gender-matched control samples. RESULTS: The data indicated that Saudi patients with autism have remarkably impaired plasma levels of the measured parameters compared to age and gender-matched controls.” | 0.95 | saudi_context_rules_v1 |
GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders.
PMID 25407263 | PMCID PMC4243332 | DOI 10.1186/s12974-014-0189-0 · Journal of neuroinflammation · 2014 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IFI16 | “The plasma levels of glutamate, GABA and glutamate/GABA ratio as markers of excitotoxicity together with TNF-α, IL-6, IFN-γ and IFI16 as markers of neuroinflammation were determined in both groups.” | 0.98 | hgnc_dict_v1 |
| phenotype | autism spectrum disorder | “GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders.” | 0.93 | phenotype_alias_lexicon_v2 |