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IRAK2 and rheumatoid arthritis are reported together in 2 articles.
Gene
IRAK2
- HGNC
- HGNC:6113
4articles
4mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Rheumatoid arthritis
212articles
212mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60IRAK2 is associated with systemic lupus erythematosus risk.
PMID 31650390 | DOI 10.1007/s10067-019-04781-1 · Clinical rheumatology · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IRAK2 | “IRAK2 is associated with systemic lupus erythematosus risk.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “IRAKs have been previously incriminated in autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis and inhibition of IRAKs has been recently regarded as a potential therapeutic strategy for SLE.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | systemic lupus erythematosus | “IRAK2 is associated with systemic lupus erythematosus risk.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs708035 | “OBJECTIVES: The aim of the present study was to test the association between IRAK2 rs708035 and rs3844283 with SLE.” | 0.90 | hgvs_regex_v1 |
IRAK2 is associated with susceptibility to rheumatoid arthritis.
PMID 29129009 | DOI 10.1007/s10067-017-3906-0 · Clinical rheumatology · 2018 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IRAK2 | “IRAK2 is associated with susceptibility to rheumatoid arthritis.” | 0.98 | hgnc_dict_v1 |
| phenotype | rheumatoid arthritis | “IRAK2 is associated with susceptibility to rheumatoid arthritis.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs3844283 | “This study was performed to investigate the association of the single nucleotide polymorphisms of interleukin-1 receptor-associated kinase 2 (IRAK2) rs3844283 and rs708035 with rheumatoid arthritis (RA).” | 0.90 | hgvs_regex_v1 |
| variant | rs708035 | “This study was performed to investigate the association of the single nucleotide polymorphisms of interleukin-1 receptor-associated kinase 2 (IRAK2) rs3844283 and rs708035 with rheumatoid arthritis (RA).” | 0.90 | hgvs_regex_v1 |