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IRF3 and obesity are reported together in 1 article.

Gene

IRF3

10articles

10mentions

0variants with confirmed gene link

Most co-reported phenotypes (articles)

Phenotype

856articles

856mentions

12co-reported genes shown

Most co-reported genes (articles)

Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.

1 records shown · first 60

PMID 36552771 | PMCID PMC9776802 | DOI 10.3390/cells11244007 · Cells · 2022 · 11 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	IRF3	“SRA1 expression associated with TLR2, IRAK1, and IRF3 expression only in individuals with obesity, regardless of diabetes status.”	0.98	hgnc_dict_v1
phenotype	obesity	“Steroid receptor RNA activator gene (SRA1) emerges as a player in pathophysiological responses of adipose tissue (AT) in metabolic disorders such as obesity and type 2 diabetes (T2D).”	0.98	phenotype_alias_lexicon_v2
gene	SRA1	“Expression of Steroid Receptor RNA Activator 1 (SRA1) in the Adipose Tissue Is Associated with TLRs and IRFs in Diabesity.”	0.98	hgnc_dict_v1
gene	IRAK1	“The gene expression of SRA1, TLRs-2,3,4,7,8,9,10 and their downstream signaling mediators including IRFs-3,4,5, myeloid differentiation factor 88 (MyD88), interleukin-1 receptor-associated kinase 1 (IRAK1), and nuclear factor-κB (NF-κB) were determined using qRT-PCR and SRA1 protein expression was determined by immunohistochemistry.”	0.98	hgnc_dict_v1