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ISG15 and COVID-19 are reported together in 2 articles.
Gene
ISG15
- HGNC
- HGNC:4053
16articles
16mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
COVID-19
1,317articles
1,317mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60SARS-CoV-2 S, M, and E Structural Glycoproteins Differentially Modulate Endoplasmic Reticulum Stress Responses.
PMID 39940816 | PMCID PMC11816748 | DOI 10.3390/ijms26031047 · International journal of molecular sciences · 2025 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ISG15 | “Gene expression differences were found in a number of interferon-stimulated genes (ISGs), including IF16, IFIT1, IFIT2, and ISG15, as well as for a number of heat shock protein (HSP) genes, including HSPH1, HSPA6, and HSPBP1, with all four SARS-CoV-2 structural proteins.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “The results suggest the SARS-CoV-2 infection can modulate an array of cell pathways, resulting in disruption to NF-κB signalling, hence providing alterations to multiple physiological responses of SARS-CoV-2-infected cells.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | IFIT1 | “Gene expression differences were found in a number of interferon-stimulated genes (ISGs), including IF16, IFIT1, IFIT2, and ISG15, as well as for a number of heat shock protein (HSP) genes, including HSPH1, HSPA6, and HSPBP1, with all four SARS-CoV-2 structural proteins.” | 0.98 | hgnc_dict_v1 |
| gene | IFIT2 | “Gene expression differences were found in a number of interferon-stimulated genes (ISGs), including IF16, IFIT1, IFIT2, and ISG15, as well as for a number of heat shock protein (HSP) genes, including HSPH1, HSPA6, and HSPBP1, with all four SARS-CoV-2 structural proteins.” | 0.98 | hgnc_dict_v1 |
Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.
PMID 32599245 | PMCID PMC7319641 | DOI 10.1016/j.ijbiomac.2020.06.228 · International journal of biological macromolecules · 2020 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ISG15 | “These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19.” | 0.98 | hgnc_dict_v1 |
| phenotype | COVID-19 | “Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | IFIT1 | “These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19.” | 0.98 | hgnc_dict_v1 |
| gene | IFITM1 | “These ISGs (IFIT1, IFITM1, IRF7, ISG15, MX1, and OAS2) can be considered as potential candidates for drug targets in the treatments of COVID-19.” | 0.98 | hgnc_dict_v1 |