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JAK1 and autism spectrum disorder are reported together in 4 articles.

Gene

JAK1

34articles

34mentions

0variants with confirmed gene link

Most co-reported phenotypes (articles)

Phenotype

881articles

881mentions

12co-reported genes shown

Most co-reported genes (articles)

Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.

4 records shown · first 60

PMID 38026692 | PMCID PMC10644687 | DOI 10.3389/fncel.2023.1268126 · Frontiers in cellular neuroscience · 2023 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	JAK1	“Children exposed to NSAIDs in early life and complicated by dysbiosis and AIH exhibited elevated serum levels of NLRP3, IL18, liver enzymes, ASMA, ANA, JAK1, and IL6.”	0.98	hgnc_dict_v1
phenotype	autism spectrum disorder	“Unveiling the interplay between NSAID-induced dysbiosis and autoimmune liver disease in children: insights into the hidden gateway to autism spectrum disorders.”	0.93	phenotype_alias_lexicon_v2
gene	NLRP3	“Furthermore, indomethacin administration led to disturbed intestinal permeability, evidenced by the activation of the NLRP3 inflammasomes pathway and elevation of downstream biomarkers (TLR4, IL18, caspase 1).”	0.98	hgnc_dict_v1
gene	TLR4	“Furthermore, indomethacin administration led to disturbed intestinal permeability, evidenced by the activation of the NLRP3 inflammasomes pathway and elevation of downstream biomarkers (TLR4, IL18, caspase 1).”	0.98	hgnc_dict_v1

PMID 31811869 | DOI 10.1016/j.neuro.2019.12.003 · Neurotoxicology · 2020 · 5 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	JAK1	“We further explored the mRNA and protein expression of IL-21, IL-22, IL-1β, TNF-α, NOS2, JAK1, STAT3, IL-27, and Foxp3 in brain tissue by RT-PCR, and western blotting.”	0.98	hgnc_dict_v1
phenotype	autism spectrum disorder	“Inhibition of tyrosine kinase signaling by tyrphostin AG126 downregulates the IL-21/IL-21R and JAK/STAT pathway in the BTBR mouse model of autism.”	0.93	phenotype_alias_lexicon_v2
gene	NOS2	“Here, using this mouse model, we investigated the effects of AG126 administration on IL-21R, IL-21, IL-22, TNF-α, NOS2, STAT3, IL-27, and Foxp3 production by CD8+ T cells in the spleen by flow cytometry.”	0.98	hgnc_dict_v1
gene	STAT3	“Here, using this mouse model, we investigated the effects of AG126 administration on IL-21R, IL-21, IL-22, TNF-α, NOS2, STAT3, IL-27, and Foxp3 production by CD8+ T cells in the spleen by flow cytometry.”	0.98	hgnc_dict_v1

PMID 29654783 | DOI 10.1016/j.ejphar.2018.04.008 · European journal of pharmacology · 2018 · 4 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	JAK1	“We also assessed the effect of resveratrol treatment on IL-6, TNF-α, IFN-γ, JAK1, and STAT3 mRNA expression levels in the brain tissue.”	0.98	hgnc_dict_v1
phenotype	autism spectrum disorder	“Autism is a neurodevelopmental disorder characterized by qualitative impairment in communication, social interaction, and repetitive stereotypic behavior.”	0.93	phenotype_alias_lexicon_v2
gene	STAT3	“We investigated the possible role of resveratrol on IL-6+, TNF-α+, IFN-γ+, and STAT3+ in CD4+ T spleen cells in BTBR mice as compared to C57BL/6J mice.”	0.98	hgnc_dict_v1
phenotype	neurodevelopmental disorder	“Autism is a neurodevelopmental disorder characterized by qualitative impairment in communication, social interaction, and repetitive stereotypic behavior.”	0.98	phenotype_alias_lexicon_v2

PMID 28802860 | DOI 10.1016/j.pnpbp.2017.08.002 · Progress in neuro-psychopharmacology & biological psychiatry · 2017 · 3 validated mentions

Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	JAK1	“We explored PBMC mRNA expression levels for IL-1β, IL-4, IFN-γ, IL-9, JAK1, and STAT5, by using real-time PCR (RT-PCR).”	0.98	hgnc_dict_v1
phenotype	autism spectrum disorder	“Upregulation of IL-9 and JAK-STAT signaling pathway in children with autism.”	0.93	phenotype_alias_lexicon_v2
phenotype	neurodevelopmental disorder	“Autism spectrum disorder (ASD) gradually develops predominantly neurodevelopmental disorders, which are socially diagnosed in early childhood.”	0.93	phenotype_alias_lexicon_v2