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JAK2 and dyslipidemia are reported together in 2 articles.
Gene
JAK2
- HGNC
- HGNC:6192
83articles
83mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
leukemia 10breast cancer 7diabetes mellitus 7hepatocellular carcinoma 6colorectal cancer 5lung cancer 3multiple myeloma 3stroke 3
Reported variants (articles · ClinVar status)
Phenotype
Dyslipidemia
338articles
338mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition.
PMID 42249096 | DOI 10.1007/s00210-026-05521-4 · Naunyn-Schmiedeberg's archives of pharmacology · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | JAK2 | “Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition.” | 0.98 | hgnc_dict_v1 |
| phenotype | dyslipidemia | “STZ‑induced diabetes caused marked hyperglycemia, reduced serum insulin, dyslipidemia, increased serum alanine and aspartate aminotransferase activities, enhanced hepatic malondialdehyde, depletion of superoxide dismutase, catalase, glutathione peroxidase, and reduced glutathione, and downregulation of the Nrf2/HO‑1 pathway.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition.” | 0.98 | hgnc_dict_v1 |
| gene | STAT1 | “Alpha‑lipoic acid-loaded chitosan nanoparticles ameliorate streptozotocin‑induced diabetic liver injury via Nrf2/HO‑1 activation and TLR4/NF‑κB and JAK2/STAT1 inhibition.” | 0.98 | hgnc_dict_v1 |
Mesenchymal stem cells improve cardiac function in diabetic rats by reducing cardiac injury biomarkers and downregulating JAK/STAT/iNOS and iNOS/Apoptosis signaling pathways.
PMID 38797354 | DOI 10.1016/j.mce.2024.112280 · Molecular and cellular endocrinology · 2024 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | JAK2 | “Administration of MSCs improved dyslipidemia, the altered cardiac injury biomarkers (p ≤ 0.0001), downregulated Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)/inducible Nitric oxide synthase (iNOS) and iNOS/Apoptosis signaling pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | dyslipidemia | “A Significant amelioration in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and dyslipidemia was noted 2 weeks post-administration of MSCs.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | STAT3 | “Administration of MSCs improved dyslipidemia, the altered cardiac injury biomarkers (p ≤ 0.0001), downregulated Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)/inducible Nitric oxide synthase (iNOS) and iNOS/Apoptosis signaling pathways.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Cardiovascular complications are prevalent manifestations of type 2 diabetes mellitus (T2DM) and are usually the main cause of death.” | 0.98 | phenotype_alias_lexicon_v2 |