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JAK2 and myocardial infarction are reported together in 2 articles.
Gene
JAK2
- HGNC
- HGNC:6192
83articles
83mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
leukemia 10breast cancer 7diabetes mellitus 7hepatocellular carcinoma 6colorectal cancer 5lung cancer 3multiple myeloma 3stroke 3
Reported variants (articles · ClinVar status)
Phenotype
Myocardial infarction
274articles
274mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60CHIP In cardiovascular and immune ageing.
PMID 42342158 | DOI 10.1016/j.arr.2026.103214 · Ageing research reviews · 2026 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | JAK2 | “Clonal hematopoiesis of indeterminate potential (CHIP) describes the proliferation of blood cell clones that carry driver mutations, such as DNA methyltransferase 3 alpha (DNMT3A), ten-eleven translocation 2 (TET2), additional sex combs like 1 (ASXL1), and Janus kinase 2 (JAK2), without leading to any obvious malignancy.” | 0.98 | hgnc_dict_v1 |
| phenotype | myocardial infarction | “In prospective cohort studies, CHIP substantially elevated the risk of myocardial infarction, stroke, and heart failure, with a relative risk increase ranging from 1.4 to 2.0-fold.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | DNMT3A | “Clonal hematopoiesis of indeterminate potential (CHIP) describes the proliferation of blood cell clones that carry driver mutations, such as DNA methyltransferase 3 alpha (DNMT3A), ten-eleven translocation 2 (TET2), additional sex combs like 1 (ASXL1), and Janus kinase 2 (JAK2), without leading to any obvious malignancy.” | 0.98 | hgnc_dict_v1 |
| gene | TET2 | “Clonal hematopoiesis of indeterminate potential (CHIP) describes the proliferation of blood cell clones that carry driver mutations, such as DNA methyltransferase 3 alpha (DNMT3A), ten-eleven translocation 2 (TET2), additional sex combs like 1 (ASXL1), and Janus kinase 2 (JAK2), without leading to any obvious malignancy.” | 0.98 | hgnc_dict_v1 |
Potential cardioprotective and regenerative effects of the fluorinated benzothiazole derivative AS09 in the myocardial infarction-induced zebrafish.
PMID 41698494 | DOI 10.1016/j.biochi.2026.02.014 · Biochimie · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | JAK2 | “Specifically, the JAK2/STAT3 pathway is a key mediator of cardiac repair and defence mechanisms.” | 0.98 | hgnc_dict_v1 |
| phenotype | myocardial infarction | “Myocardial infarction (MI), a significant complication of coronary artery disease (CAD), results from prolonged myocardial ischemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | STAT3 | “Specifically, the JAK2/STAT3 pathway is a key mediator of cardiac repair and defence mechanisms.” | 0.98 | hgnc_dict_v1 |
| gene | GSK3B | “The in silico studies preliminarily revealed the potential interactions of AS09 with MI targets (JAK2, GSK3B, and PIK3CA).” | 0.98 | hgnc_dict_v1 |