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KCNQ1 and diabetes mellitus are reported together in 8 articles.
Gene
KCNQ1
- HGNC
- HGNC:6294
24articles
24mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
long QT syndrome 9arrhythmia 8diabetes mellitus 8hearing loss 4Ehlers-Danlos syndrome 1Turner syndrome 1congenital myopathy 1coronary artery disease 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
8 records shown · first 60Saudi Community-Based Screening Study on Genetic Variants in β-Cell Dysfunction and Its Role in Women with Gestational Diabetes Mellitus.
PMID 37107681 | PMCID PMC10137495 | DOI 10.3390/genes14040924 · Genes · 2023 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KCNQ1 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Saudi Community-Based Screening Study on Genetic Variants in β-Cell Dysfunction and Its Role in Women with Gestational Diabetes Mellitus.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TCF7L2 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
| gene | KCNJ11 | “TCF7L2, KCNQ1, and KCNJ11 genes are connected to the mechanism of β-cell dysfunction.” | 0.98 | hgnc_dict_v1 |
Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study.
PMID 33101408 | PMCID PMC7569458 | DOI 10.1155/2020/5924756 · International journal of endocrinology · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KCNQ1 | “Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | KCNJ11 | “Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study.” | 0.98 | hgnc_dict_v1 |
| variant | rs5210 | “The aim of this study was to find risk associated with genetic variants rs5210 and rs2237895 of KCNJ11 and KCNQ1 genes, respectively, in the development of T2DM in the Indian population.” | 0.90 | hgvs_regex_v1 |
Impact of variants on type-2 diabetes risk genes identified through genomewide association studies in polycystic ovary syndrome: a case-control study.
PMID 30555071 · Journal of genetics · 2018 · 14 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KCNQ1 | “To address this, we examined the association between the T2D GWAS candidate genes (CDKAL1, CDKN2B, COL8A1, HHEX, IGF2BP2, KCNJ1, KCNQ1 and SLC30A8) and PCOS in Saudi women.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Impact of variants on type-2 diabetes risk genes identified through genomewide association studies in polycystic ovary syndrome: a case-control study.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CDKAL1 | “To address this, we examined the association between the T2D GWAS candidate genes (CDKAL1, CDKN2B, COL8A1, HHEX, IGF2BP2, KCNJ1, KCNQ1 and SLC30A8) and PCOS in Saudi women.” | 0.98 | hgnc_dict_v1 |
| gene | CDKN2B | “To address this, we examined the association between the T2D GWAS candidate genes (CDKAL1, CDKN2B, COL8A1, HHEX, IGF2BP2, KCNJ1, KCNQ1 and SLC30A8) and PCOS in Saudi women.” | 0.98 | hgnc_dict_v1 |
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.
PMID 28490609 | PMCID PMC5521867 | DOI 10.2337/db16-1452 · Diabetes · 2017 · 17 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KCNQ1 | “Thirty type 2 diabetes or fasting glucose-raising alleles were associated with a measure of first-phase insulin secretion at P < 0.05 and provided new evidence, or the strongest evidence yet, that insulin secretion, intrinsic to the islet cells, is a key mechanism underlying the associations at the HNF1A, IGF2BP2, KCNQ1, HNF1B, VPS13C/C2CD4A, FAF1, PTPRD, AP3S2, KCNK16, MAEA, LPP, WFS1, and TMPRSS6 loci.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HNF1A | “Thirty type 2 diabetes or fasting glucose-raising alleles were associated with a measure of first-phase insulin secretion at P < 0.05 and provided new evidence, or the strongest evidence yet, that insulin secretion, intrinsic to the islet cells, is a key mechanism underlying the associations at the HNF1A, IGF2BP2, KCNQ1, HNF1B, VPS13C/C2CD4A, FAF1, PTPRD, AP3S2, KCNK16, MAEA, LPP, WFS1, and TMPRSS6 loci.” | 0.98 | hgnc_dict_v1 |
| gene | IGF2BP2 | “Thirty type 2 diabetes or fasting glucose-raising alleles were associated with a measure of first-phase insulin secretion at P < 0.05 and provided new evidence, or the strongest evidence yet, that insulin secretion, intrinsic to the islet cells, is a key mechanism underlying the associations at the HNF1A, IGF2BP2, KCNQ1, HNF1B, VPS13C/C2CD4A, FAF1, PTPRD, AP3S2, KCNK16, MAEA, LPP, WFS1, and TMPRSS6 loci.” | 0.98 | hgnc_dict_v1 |
Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population.
PMID 28863213 | PMCID PMC5596376 | DOI 10.1590/1678-4685-GMB-2017-0005 · Genetics and molecular biology · 2017 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KCNQ1 | “Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population.” | 0.93 | phenotype_alias_lexicon_v2 |
| population | Saudi Arabia | “Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population. Patients diagnosed with either T2D (320 patients), CVD (250 patients) or both (60 patients) and 516 healthy controls were genotyped by TaqMan assay run on a real time PCR thermocycler.” | 0.95 | saudi_context_rules_v1 |
| variant | rs2237892 | “The current study was undertaken to evaluate the association of 3 polymorphisms of KCNQ1 (rs2237892, rs151290 and rs2237895) with T2D and/or CVD.” | 0.90 | hgvs_regex_v1 |
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
PMID 26551672 | PMCID PMC4666734 | DOI 10.1038/ng.3437 · Nature genetics · 2015 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KCNQ1 | “We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | FOXA2 | “Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association.” | 0.98 | hgnc_dict_v1 |
| gene | MTNR1B | “Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association.” | 0.98 | hgnc_dict_v1 |
Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the Saudi Arabian Population.
PMID 23448427 | DOI 10.1111/cen.12187 · Clinical endocrinology · 2014 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KCNQ1 | “CONCLUSIONS: We have shown for the first time that variants at WFS1, JAZF1, SLC30A8, CDKN2A/B, TCF7L2, KCNQ1, HMG20A, HNF4A and DUSP9 are associated with T2D in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the Saudi Arabian Population.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | HNF4A | “The effect sizes of these loci were comparable to those previously identified in other populations with the exception of HNF4A, which showed a trend for larger effect size in our study population (OR = 1·27) compared to that reported in South Asian populations (OR = 1·09; I(2) = 65·9).” | 0.98 | hgnc_dict_v1 |
| gene | SLC30A8 | “Analysis of a subgroup of subjects with BMI≤30 resulted in two additional loci (SLC30A8; P = 0·03, HMG20A; P = 0·02) showing significant association with T2D.” | 0.98 | hgnc_dict_v1 |
Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population.
PMID 25501231 | DOI 10.4238/2014.December.4.14 · Genetics and molecular research : GMR · 2014 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KCNQ1 | “Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | FTO | “Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | MC4R | “Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population.” | 0.98 | hgnc_dict_v1 |