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KRAS and diabetes mellitus are reported together in 2 articles.
Gene
KRAS
- HGNC
- HGNC:6407
119articles
119mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 41lung cancer 19thyroid cancer 10breast cancer 5lymphoma 3diabetes mellitus 2leukemia 2cardiomyopathy 1
Reported variants (articles · ClinVar status)
Phenotype
Diabetes mellitus
2,156articles
2,156mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Repurposing DPP-4 inhibitors as anticancer agents in KRAS-mutated pancreatic ductal adenocarcinoma.
PMID 41361888 | PMCID PMC12687489 | DOI 10.1186/s40360-025-01020-z · BMC pharmacology & toxicology · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KRAS | “METHODS: In the current study, we examined the therapeutic potential of these DPP-4 inhibitors in proliferation, wound healing, and colony formation, ROS induction, DNA fragmentation, apoptosis induction, and regulation of gene expression in KRAS G12C-mutated MIA PaCa-2 & KRAS G12D-mutated PANC-1 PDAC cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Sitagliptin and Linagliptin are Dipeptidyl Peptidase-4 (DPP-4) inhibitors, which are being used to manage Type 2 Diabetes Mellitus (T2DM).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MIA | “METHODS: In the current study, we examined the therapeutic potential of these DPP-4 inhibitors in proliferation, wound healing, and colony formation, ROS induction, DNA fragmentation, apoptosis induction, and regulation of gene expression in KRAS G12C-mutated MIA PaCa-2 & KRAS G12D-mutated PANC-1 PDAC cells.” | 0.98 | hgnc_dict_v1 |
Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer.
PMID 32939513 | PMCID PMC7490123 | DOI 10.1055/s-0040-1714415 · Global medical genetics · 2020 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KRAS | “Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer.” | 0.98 | hgnc_dict_v1 |
| phenotype | diabetes mellitus | “Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | colorectal cancer | “Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer.” | 0.93 | phenotype_alias_lexicon_v2 |