Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
KRAS and leukemia are reported together in 2 articles.
Gene
KRAS
- HGNC
- HGNC:6407
119articles
119mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 41lung cancer 19thyroid cancer 10breast cancer 5lymphoma 3diabetes mellitus 2leukemia 2cardiomyopathy 1
Reported variants (articles · ClinVar status)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Analysis of RAS gene mutations in cytogenetically normal de novo acute myeloid leukemia patients reveals some novel alterations.
PMID 34220225 | PMCID PMC8241590 | DOI 10.1016/j.sjbs.2021.04.089 · Saudi journal of biological sciences · 2021 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KRAS | “The activated mutations in Neuroblastoma rat sarcoma viral oncogene homolog (NRAS) and Kirsten rat sarcoma viral oncogene homolog (KRAS) confers proliferative and survival signals, deliberating numerous effects on overall survival and progression free survival in AML patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Analysis of RAS gene mutations in cytogenetically normal de novo acute myeloid leukemia patients reveals some novel alterations.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | NRAS | “The activated mutations in Neuroblastoma rat sarcoma viral oncogene homolog (NRAS) and Kirsten rat sarcoma viral oncogene homolog (KRAS) confers proliferative and survival signals, deliberating numerous effects on overall survival and progression free survival in AML patients.” | 0.98 | hgnc_dict_v1 |
| gene | CD34 | “In addition there was no statistically significant association of mutRAS gene of AML patients with several prognostic markers including age, gender, karyotyping, CD34 positivity, cytogenetic abnormalities, total leukocyte count, white blood cell count and French-American-British (FAB) classification.” | 0.98 | hgnc_dict_v1 |
Utility of next-generation sequencing technologies for the efficient genetic resolution of haematological disorders.
PMID 25703294 | DOI 10.1111/cge.12573 · Clinical genetics · 2016 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KRAS | “The final two cases (MYH9 associated macrothrombocytopenia associated with multiple congenital anomalies; atypical juvenile myelomonocytic leukaemia associated with a KRAS mutation) highlight the utility of NGS where the diagnosis is less certain, or where there is an unusual phenotype.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “The final two cases (MYH9 associated macrothrombocytopenia associated with multiple congenital anomalies; atypical juvenile myelomonocytic leukaemia associated with a KRAS mutation) highlight the utility of NGS where the diagnosis is less certain, or where there is an unusual phenotype.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | RPS19 | “Mutations in RPS19, ELANE and FANCD2 were found.” | 0.98 | hgnc_dict_v1 |
| gene | ELANE | “Mutations in RPS19, ELANE and FANCD2 were found.” | 0.98 | hgnc_dict_v1 |