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KRAS and lymphoma are reported together in 3 articles.
Gene
KRAS
- HGNC
- HGNC:6407
119articles
119mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 41lung cancer 19thyroid cancer 10breast cancer 5lymphoma 3diabetes mellitus 2leukemia 2cardiomyopathy 1
Reported variants (articles · ClinVar status)
Phenotype
Lymphoma
428articles
428mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Recent Developments and Challenges in Molecular-Targeted Therapy of Non-Small-Cell Lung Cancer.
PMID 36734951 | DOI 10.1615/JEnvironPatholToxicolOncol.2022042983 · Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer · 2023 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KRAS | “Molecular abnormalities related to epidermal growth factor receptor (EGFR), v-Raf murine sarcoma viral oncogene homolog B1 (B-RAF) Kirsten rat sarcoma virus (KRAS) mutations, translocation of the anaplastic lymphoma kinase (ALK) gene, mesenchymal-epithelial transition factor (MET) amplification have been studied to overcome the resistance and to develop new therapies for non-small cell lung cancer (NSCLC).” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “Molecular abnormalities related to epidermal growth factor receptor (EGFR), v-Raf murine sarcoma viral oncogene homolog B1 (B-RAF) Kirsten rat sarcoma virus (KRAS) mutations, translocation of the anaplastic lymphoma kinase (ALK) gene, mesenchymal-epithelial transition factor (MET) amplification have been studied to overcome the resistance and to develop new therapies for non-small cell lung cancer (NSCLC).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Molecular abnormalities related to epidermal growth factor receptor (EGFR), v-Raf murine sarcoma viral oncogene homolog B1 (B-RAF) Kirsten rat sarcoma virus (KRAS) mutations, translocation of the anaplastic lymphoma kinase (ALK) gene, mesenchymal-epithelial transition factor (MET) amplification have been studied to overcome the resistance and to develop new therapies for non-small cell lung cancer (NSCLC).” | 0.98 | hgnc_dict_v1 |
| gene | ALK | “Molecular abnormalities related to epidermal growth factor receptor (EGFR), v-Raf murine sarcoma viral oncogene homolog B1 (B-RAF) Kirsten rat sarcoma virus (KRAS) mutations, translocation of the anaplastic lymphoma kinase (ALK) gene, mesenchymal-epithelial transition factor (MET) amplification have been studied to overcome the resistance and to develop new therapies for non-small cell lung cancer (NSCLC).” | 0.98 | hgnc_dict_v1 |
The Role of Tissue and Liquid Biopsy in the Clinical Management of Adult Lung Cancer Patients in King Abdul-Aziz Medical City in Riyadh, Saudi Arabia.
PMID 35004079 | PMCID PMC8724526 | DOI 10.7759/cureus.20914 · Cureus · 2022 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KRAS | “For a panel of 12 genes, 25% had the tumor protein 53 (TP53) gene mutation and 39% had the gene Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “For the anaplastic lymphoma kinase (ALK) gene, 13% were found to be mutated; for the ROS proto-oncogene 1 (ROS1) gene, only 7% were seen to be mutated.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Single gene testing for epidermal growth factor receptor (EGFR) for patients who underwent tissue biopsy showed a 35% mutation rate.” | 0.98 | hgnc_dict_v1 |
| gene | ALK | “For the anaplastic lymphoma kinase (ALK) gene, 13% were found to be mutated; for the ROS proto-oncogene 1 (ROS1) gene, only 7% were seen to be mutated.” | 0.98 | hgnc_dict_v1 |
IQGAP1 gene silencing induces apoptosis and decreases the invasive capacity of human hepatocellular carcinoma cells.
PMID 27488117 | DOI 10.1007/s13277-016-5283-8 · Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016 · 11 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KRAS | “Furthermore, we observed that the mRNA levels of HRAS, KRAS, NRAS, and MRAS decreased upon IQGAP1 silencing.” | 0.98 | hgnc_dict_v1 |
| phenotype | lymphoma | “We investigated the impact of IQGAP1 silencing on the interactions of IQGAP and RAS with several apoptotic proteins, including caspase-3 (CASP3), BCL2-associated X protein (BAX), and B-cell leukemia/lymphoma 2 (BCL2).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | IQGAP1 | “IQGAP1 gene silencing induces apoptosis and decreases the invasive capacity of human hepatocellular carcinoma cells.” | 0.98 | hgnc_dict_v1 |
| gene | IQGAP2 | “IQGAP1 is expressed in all cells, while IQGAP2 and IQGAP3 are mainly expressed in hepatic cells.” | 0.98 | hgnc_dict_v1 |