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KRAS and ovarian cancer are reported together in 1 article.
Gene
KRAS
- HGNC
- HGNC:6407
119articles
119mentions
2variants with confirmed gene link
Most co-reported phenotypes (articles)
colorectal cancer 41lung cancer 19thyroid cancer 10breast cancer 5lymphoma 3diabetes mellitus 2leukemia 2cardiomyopathy 1
Reported variants (articles · ClinVar status)
Phenotype
Ovarian cancer
173articles
173mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60PIK3CA alterations in Middle Eastern ovarian cancers.
PMID 19638206 | PMCID PMC2724395 | DOI 10.1186/1476-4598-8-51 · Molecular cancer · 2009 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KRAS | “PIK3CA amplification was seen in 54 of 152 (35.5%) EOC cases analyzed; PIK3CA gene mutations in 6/153 EOC (3.9%); KRAS mutations in 3/154 EOC (1.9%), BRAF mutations in 3/156 EOC (1.9%), p53 mutation in 50/154 EOC (32.5%), and loss of PTEN protein expression in 33/144 EOC (22.9%). p110 alpha overexpression was associated with increased phosphorylation of AKT-Ser 473 and with the proliferation marker Ki-67.” | 0.98 | hgnc_dict_v1 |
| phenotype | ovarian cancer | “However the role of this oncogenic signaling pathway has not been explored in the Middle Eastern epithelial ovarian cancer (EOC).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PIK3CA | “PIK3CA alterations in Middle Eastern ovarian cancers.” | 0.98 | hgnc_dict_v1 |
| gene | PTEN | “Therefore, we investigated PI3K/AKT genetic alterations such as PIK3CA amplification, PIK3CA mutation, PTEN protein loss and their relationships with various clinicopathological characteristics in 156 EOCs.” | 0.98 | hgnc_dict_v1 |