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LDLR and Alzheimer disease are reported together in 1 article.
Gene
LDLR
- HGNC
- HGNC:6547
61articles
61mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
familial hypercholesterolemia 40coronary artery disease 8dyslipidemia 6diabetes mellitus 5hypertension 4obesity 4myocardial infarction 3Down syndrome 2
Reported variants (articles · ClinVar status)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.
PMID 42362005 | DOI 10.1016/j.mcn.2026.104108 · Molecular and cellular neurosciences · 2026 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LDLR | “One of the key functions of APOE is to bind and deliver newly synthesized cholesterol and lipids to neurons through receptor-mediated endocytosis (LDLR, LRP1, VLDLR, APOER2).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | APOE | “Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.” | 0.98 | hgnc_dict_v1 |
| gene | LRP1 | “One of the key functions of APOE is to bind and deliver newly synthesized cholesterol and lipids to neurons through receptor-mediated endocytosis (LDLR, LRP1, VLDLR, APOER2).” | 0.98 | hgnc_dict_v1 |