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LDLR and SARS are reported together in 1 article.
Gene
LDLR
- HGNC
- HGNC:6547
61articles
61mentions
10variants with confirmed gene link (top 10)
Most co-reported phenotypes (articles)
familial hypercholesterolemia 40coronary artery disease 8dyslipidemia 6diabetes mellitus 5hypertension 4obesity 4myocardial infarction 3Down syndrome 2
Reported variants (articles · ClinVar status)
Phenotype
SARS
347articles
347mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection.
PMID 38528584 | PMCID PMC10962113 | DOI 10.1186/s12934-024-02355-8 · Microbial cell factories · 2024 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LDLR | “The pivotal role that proprotein convertase subtilisin/kexin Type 9 (PCSK9) plays in cholesterol homeostasis and atherosclerosis, primarily by post-transcriptionally regulating hepatic low-density lipoprotein receptor (LDLR) and promoting its lysosomal degradation, has garnered increasing interest.” | 0.98 | hgnc_dict_v1 |
| phenotype | SARS | “Furthermore, PCSK9 inhibition has been suggested to protect against dengue virus (DENV) potentially and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | PCSK9 | “Potential use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition and prevention method in viral infection.” | 0.98 | hgnc_dict_v1 |
| phenotype | hepatitis C | “In addition to the current inquiry into the potential therapeutic application of PCSK9 inhibition in human immunodeficiency virus (HIV)-infected patients for hyperlipidemia associated with HIV and antiretroviral therapy (ART), preclinical research suggests that PCSK9 may also play a role in inhibiting hepatitis C virus (HCV) replication.” | 0.98 | phenotype_alias_lexicon_v2 |