Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
LRP1 and Alzheimer disease are reported together in 3 articles.
Gene
LRP1
- HGNC
- HGNC:6692
8articles
8mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Alzheimer disease 3Marfan syndrome 1Parkinson disease 1congenital heart disease 1coronary artery disease 1diabetes mellitus 1epilepsy 1
Reported variants (articles · ClinVar status)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.
PMID 42362005 | DOI 10.1016/j.mcn.2026.104108 · Molecular and cellular neurosciences · 2026 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LRP1 | “One of the key functions of APOE is to bind and deliver newly synthesized cholesterol and lipids to neurons through receptor-mediated endocytosis (LDLR, LRP1, VLDLR, APOER2).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | APOE | “Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.” | 0.98 | hgnc_dict_v1 |
| gene | LDLR | “One of the key functions of APOE is to bind and deliver newly synthesized cholesterol and lipids to neurons through receptor-mediated endocytosis (LDLR, LRP1, VLDLR, APOER2).” | 0.98 | hgnc_dict_v1 |
LRP1 at the crossroads of Parkinson's and Alzheimer's: Divergent roles in α-synuclein and amyloid pathology.
PMID 40484331 | DOI 10.1016/j.ejphar.2025.177830 · European journal of pharmacology · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LRP1 | “LRP1 at the crossroads of Parkinson's and Alzheimer's: Divergent roles in α-synuclein and amyloid pathology.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Additionally, amyloid protein (Aβ) and tau protein, which are the hallmarks of Alzheimer's disease (AD), are also involved in PD and the development of PD-related dementia.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | Parkinson disease | “Parkinson's disease (PD) is the second most common neurodegenerative disease that represents the commonest movement disorder in the elderly population.” | 0.93 | phenotype_alias_lexicon_v2 |
The potential anti-Alzheimer's activity of Oxalis corniculata Linn. Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues.
PMID 38218505 | DOI 10.1016/j.jep.2024.117731 · Journal of ethnopharmacology · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LRP1 | “Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “One of the most prevalent neurodegenerative disorders is Alzheimer's disease (AD) in which neuroinflammation and oxidative stress are its main pathogenic processes.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | TLR4 | “Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues.” | 0.98 | hgnc_dict_v1 |