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LRP1 and Parkinson disease are reported together in 1 article.
Gene
LRP1
- HGNC
- HGNC:6692
8articles
8mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Alzheimer disease 3Marfan syndrome 1Parkinson disease 1congenital heart disease 1coronary artery disease 1diabetes mellitus 1epilepsy 1
Reported variants (articles · ClinVar status)
Phenotype
Parkinson disease
280articles
280mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60LRP1 at the crossroads of Parkinson's and Alzheimer's: Divergent roles in α-synuclein and amyloid pathology.
PMID 40484331 | DOI 10.1016/j.ejphar.2025.177830 · European journal of pharmacology · 2025 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LRP1 | “LRP1 at the crossroads of Parkinson's and Alzheimer's: Divergent roles in α-synuclein and amyloid pathology.” | 0.98 | hgnc_dict_v1 |
| phenotype | Parkinson disease | “Parkinson's disease (PD) is the second most common neurodegenerative disease that represents the commonest movement disorder in the elderly population.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | Alzheimer disease | “Additionally, amyloid protein (Aβ) and tau protein, which are the hallmarks of Alzheimer's disease (AD), are also involved in PD and the development of PD-related dementia.” | 0.93 | phenotype_alias_lexicon_v2 |