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LRRK2 and inflammatory bowel disease are reported together in 2 articles.
Gene
LRRK2
- HGNC
- HGNC:18618
18articles
18mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Parkinson disease 14inflammatory bowel disease 2ulcerative colitis 2Alzheimer disease 1asthma 1breast cancer 1multiple sclerosis 1
Reported variants (articles · ClinVar status)
Phenotype
Inflammatory bowel disease
693articles
693mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Casuarina glauca branchlets' extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies.
PMID 38196993 | PMCID PMC10774231 | DOI 10.3389/fphar.2023.1322181 · Frontiers in pharmacology · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LRRK2 | “Network pharmacology analysis revealed 171 potential UC targets for the bioactive compounds, including EGFR, LRRK2, and HSP90 as top targets, which were found to bind to key CGBRE compounds through molecular docking.” | 0.98 | hgnc_dict_v1 |
| phenotype | inflammatory bowel disease | “Ulcerative colitis (UC) is an inflammatory bowel disease that is often resistant to current treatment options, leading to a need for alternative therapies.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Network pharmacology analysis revealed 171 potential UC targets for the bioactive compounds, including EGFR, LRRK2, and HSP90 as top targets, which were found to bind to key CGBRE compounds through molecular docking.” | 0.98 | hgnc_dict_v1 |
| phenotype | ulcerative colitis | “Casuarina glauca branchlets' extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies.” | 0.98 | phenotype_alias_lexicon_v2 |
Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2.
PMID 30223621 | PMCID PMC6165039 | DOI 10.3390/ijms19092784 · International journal of molecular sciences · 2018 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LRRK2 | “Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2.” | 0.98 | hgnc_dict_v1 |
| phenotype | inflammatory bowel disease | “Rare mutations in the LRRK2 gene cause familial Parkinson's disease (PD) and inflammatory bowel disease.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | Parkinson disease | “Rare mutations in the LRRK2 gene cause familial Parkinson's disease (PD) and inflammatory bowel disease.” | 0.93 | phenotype_alias_lexicon_v2 |