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LRRK2 and multiple sclerosis are reported together in 1 article.
Gene
LRRK2
- HGNC
- HGNC:18618
18articles
18mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Parkinson disease 14inflammatory bowel disease 2ulcerative colitis 2Alzheimer disease 1asthma 1breast cancer 1multiple sclerosis 1
Reported variants (articles · ClinVar status)
Phenotype
Multiple sclerosis
236articles
236mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60Unraveling the metabolic potential of Moringa oleifera derived metabolites in combating Parkinson's and Alzheimer's disease.
PMID 41478196 | DOI 10.1016/j.bioorg.2025.109442 · Bioorganic chemistry · 2026 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LRRK2 | “To enhance the reliability and translational relevance of the computational predictions, experimentally validated inhibitors lanabecestat (APP inhibitor), GNE0877 (LRRK2 inhibitor), and olaparib (PARP1 inhibitor) were included as positive controls to benchmark the binding affinity and interaction stability of moringa metabolites.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “In total, 72 metabolites derived from moringa were screened against the ten genes, the overexpression of which was reported in five related disease conditions, including Alzheimer's, Parkinson's, Kidney Stones, Multiple Sclerosis, and Asthma diseases.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PARP1 | “To enhance the reliability and translational relevance of the computational predictions, experimentally validated inhibitors lanabecestat (APP inhibitor), GNE0877 (LRRK2 inhibitor), and olaparib (PARP1 inhibitor) were included as positive controls to benchmark the binding affinity and interaction stability of moringa metabolites.” | 0.98 | hgnc_dict_v1 |
| phenotype | asthma | “In total, 72 metabolites derived from moringa were screened against the ten genes, the overexpression of which was reported in five related disease conditions, including Alzheimer's, Parkinson's, Kidney Stones, Multiple Sclerosis, and Asthma diseases.” | 0.98 | phenotype_alias_lexicon_v2 |