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LRRK2 and ulcerative colitis are reported together in 2 articles.
Gene
LRRK2
- HGNC
- HGNC:18618
18articles
18mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Parkinson disease 14inflammatory bowel disease 2ulcerative colitis 2Alzheimer disease 1asthma 1breast cancer 1multiple sclerosis 1
Reported variants (articles · ClinVar status)
Phenotype
Ulcerative colitis
492articles
492mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Trimetazidine Attenuates Ulcerative Colitis-Linked Extrapyramidal Dysfunction by Mediated Dectin-1/LRRK2/α-Synuclein Autophagy Axis.
PMID 41566671 | DOI 10.1093/mam/ozaf118 · Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LRRK2 | “Trimetazidine Attenuates Ulcerative Colitis-Linked Extrapyramidal Dysfunction by Mediated Dectin-1/LRRK2/α-Synuclein Autophagy Axis.” | 0.98 | hgnc_dict_v1 |
| phenotype | ulcerative colitis | “Chronic relapsing colonic inflammation, specifically ulcerative colitis (UC), causes persistent mucosal injury and disrupts the gut-brain axis.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | LAMP2 | “Furthermore, TMZ restored autophagic flux by reducing P62 accumulation and enhancing LAMP2 expression.” | 0.98 | hgnc_dict_v1 |
Casuarina glauca branchlets' extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies.
PMID 38196993 | PMCID PMC10774231 | DOI 10.3389/fphar.2023.1322181 · Frontiers in pharmacology · 2023 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | LRRK2 | “Network pharmacology analysis revealed 171 potential UC targets for the bioactive compounds, including EGFR, LRRK2, and HSP90 as top targets, which were found to bind to key CGBRE compounds through molecular docking.” | 0.98 | hgnc_dict_v1 |
| phenotype | ulcerative colitis | “Casuarina glauca branchlets' extract as a potential treatment for ulcerative colitis: chemical composition, in silico and in vivo studies.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Network pharmacology analysis revealed 171 potential UC targets for the bioactive compounds, including EGFR, LRRK2, and HSP90 as top targets, which were found to bind to key CGBRE compounds through molecular docking.” | 0.98 | hgnc_dict_v1 |
| phenotype | inflammatory bowel disease | “Ulcerative colitis (UC) is an inflammatory bowel disease that is often resistant to current treatment options, leading to a need for alternative therapies.” | 0.98 | phenotype_alias_lexicon_v2 |