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MAPT and Alzheimer disease are reported together in 5 articles.
Gene
MAPT
- HGNC
- HGNC:6893
9articles
9mentions
1variants with confirmed gene link
Most co-reported phenotypes (articles)
Reported variants (articles · ClinVar status)
Phenotype
Alzheimer disease
455articles
455mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
5 records shown · first 60CRISPR-Cas9 and next-generation gene editing strategies for therapeutic intervention of neurodegenerative pathways in Alzheimer's disease: a state-of-the-art review.
PMID 41931258 | DOI 10.1007/s13760-026-03033-9 · Acta neurologica Belgica · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MAPT | “We discuss targeting of critical genes such as APOE4, APP, PSEN1, PSEN2, and MAPT, which play central roles in amyloid processing, tau pathology, lipid metabolism, and neuroinflammatory cascades, and evaluate strategies for allele-specific correction, gene silencing, and transcriptional regulation using CRISPR interference/activation and epigenome editing tools.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “CRISPR-Cas9 and next-generation gene editing strategies for therapeutic intervention of neurodegenerative pathways in Alzheimer's disease: a state-of-the-art review.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | APP | “We discuss targeting of critical genes such as APOE4, APP, PSEN1, PSEN2, and MAPT, which play central roles in amyloid processing, tau pathology, lipid metabolism, and neuroinflammatory cascades, and evaluate strategies for allele-specific correction, gene silencing, and transcriptional regulation using CRISPR interference/activation and epigenome editing tools.” | 0.98 | hgnc_dict_v1 |
| gene | PSEN1 | “We discuss targeting of critical genes such as APOE4, APP, PSEN1, PSEN2, and MAPT, which play central roles in amyloid processing, tau pathology, lipid metabolism, and neuroinflammatory cascades, and evaluate strategies for allele-specific correction, gene silencing, and transcriptional regulation using CRISPR interference/activation and epigenome editing tools.” | 0.98 | hgnc_dict_v1 |
CNV-Finder: Streamlining Copy Number Variation Discovery.
PMID 39605431 | PMCID PMC11601614 | DOI 10.1101/2024.11.22.624040 · bioRxiv : the preprint server for biology · 2025 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MAPT | “We incorporate four genes to establish our methods-Parkin (PRKN), Leucine Rich Repeat And Ig Domain Containing 2 (LINGO2), Microtubule Associated Protein Tau (MAPT), and alpha-Synuclein (SNCA)-which may be relevant to neurological diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Progressive Supranuclear Palsy (PSP), or related disorders such as essential tremor (ET).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “We incorporate four genes to establish our methods-Parkin (PRKN), Leucine Rich Repeat And Ig Domain Containing 2 (LINGO2), Microtubule Associated Protein Tau (MAPT), and alpha-Synuclein (SNCA)-which may be relevant to neurological diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Progressive Supranuclear Palsy (PSP), or related disorders such as essential tremor (ET).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | PRKN | “We incorporate four genes to establish our methods-Parkin (PRKN), Leucine Rich Repeat And Ig Domain Containing 2 (LINGO2), Microtubule Associated Protein Tau (MAPT), and alpha-Synuclein (SNCA)-which may be relevant to neurological diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Progressive Supranuclear Palsy (PSP), or related disorders such as essential tremor (ET).” | 0.98 | hgnc_dict_v1 |
| gene | LINGO2 | “We incorporate four genes to establish our methods-Parkin (PRKN), Leucine Rich Repeat And Ig Domain Containing 2 (LINGO2), Microtubule Associated Protein Tau (MAPT), and alpha-Synuclein (SNCA)-which may be relevant to neurological diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Progressive Supranuclear Palsy (PSP), or related disorders such as essential tremor (ET).” | 0.98 | hgnc_dict_v1 |
Multiple system atrophy with amyloid-β-predominant Alzheimer's disease neuropathologic change.
PMID 38712319 | PMCID PMC11073746 | DOI 10.1093/braincomms/fcae141 · Brain communications · 2024 · 6 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MAPT | “We performed genetic testing for APOE, MAPT, PSEN1, PSEN2 and APP.” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Multiple system atrophy with amyloid-β-predominant Alzheimer's disease neuropathologic change.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | APOE | “We performed genetic testing for APOE, MAPT, PSEN1, PSEN2 and APP.” | 0.98 | hgnc_dict_v1 |
| gene | PSEN1 | “We performed genetic testing for APOE, MAPT, PSEN1, PSEN2 and APP.” | 0.98 | hgnc_dict_v1 |
Transcript-Level In Silico Analysis of Alzheimer's Disease-Related Gene Biomarkers and Their Evaluation with Bioactive Flavonoids to Explore Therapeutic Interactions.
PMID 37929088 | PMCID PMC10621018 | DOI 10.1021/acsomega.3c05769 · ACS omega · 2023 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MAPT | “According to the NIA-AA (National Institute on Aging-Alzheimer's Association) framework, we selected three AD biomarker genes (APP, NEFL, and MAPT).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “Alzheimer's disease (AD) is a progressive brain disorder that can significantly affect the quality of life.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | APP | “According to the NIA-AA (National Institute on Aging-Alzheimer's Association) framework, we selected three AD biomarker genes (APP, NEFL, and MAPT).” | 0.98 | hgnc_dict_v1 |
| gene | NEFL | “According to the NIA-AA (National Institute on Aging-Alzheimer's Association) framework, we selected three AD biomarker genes (APP, NEFL, and MAPT).” | 0.98 | hgnc_dict_v1 |
Developmental exposure to lead (Pb) alters the expression of the human tau gene and its products in a transgenic animal model.
PMID 27293183 | PMCID PMC5738909 | DOI 10.1016/j.neuro.2016.06.001 · Neurotoxicology · 2016 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MAPT | “The best known of these illnesses is Alzheimer's disease (AD); a disease where the microtubule associated protein tau (MAPT) becomes hyperphosphorylated (lowering its binding affinity to microtubules) and aggregates within neurons in the form of neurofibrillary tangles (NFTs).” | 0.98 | hgnc_dict_v1 |
| phenotype | Alzheimer disease | “The best known of these illnesses is Alzheimer's disease (AD); a disease where the microtubule associated protein tau (MAPT) becomes hyperphosphorylated (lowering its binding affinity to microtubules) and aggregates within neurons in the form of neurofibrillary tangles (NFTs).” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | CDK5 | “Protein and mRNA levels for tau and CDK5 as well as tau phosphorylation at Ser396 were determined.” | 0.98 | hgnc_dict_v1 |