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MBP and multiple sclerosis are reported together in 4 articles.
Gene
MBP
- HGNC
- HGNC:6925
12articles
12mentions
3variants with confirmed gene link
Most co-reported phenotypes (articles)
multiple sclerosis 4Alzheimer disease 1amyotrophic lateral sclerosis 1arrhythmia 1congenital cataract 1diabetes mellitus 1epilepsy 1skeletal dysplasia 1
Reported variants (articles · ClinVar status)
Phenotype
Multiple sclerosis
236articles
236mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
4 records shown · first 60Decoding the genetic basis of demyelination: Prediction of potential pathogenic coding and regulatory noncoding MBP SNPs in multiple sclerosis.
PMID 42166461 | PMCID PMC13193510 | DOI 10.1371/journal.pone.0347598 · PloS one · 2026 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MBP | “Decoding the genetic basis of demyelination: Prediction of potential pathogenic coding and regulatory noncoding MBP SNPs in multiple sclerosis.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “Decoding the genetic basis of demyelination: Prediction of potential pathogenic coding and regulatory noncoding MBP SNPs in multiple sclerosis.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | rs1971676214 | “Moreover, three nsSNPs, rs1971676214 (D173E), rs1242552448 (D173H), and rs772570115 (G176W), were consistently predicted to be pathogenic and to destabilize the protein structure.” | 0.90 | hgvs_regex_v1 |
| variant | rs1242552448 | “Moreover, three nsSNPs, rs1971676214 (D173E), rs1242552448 (D173H), and rs772570115 (G176W), were consistently predicted to be pathogenic and to destabilize the protein structure.” | 0.90 | hgvs_regex_v1 |
Vanillic Acid Ameliorates Demyelination in a Cuprizone-Induced Multiple Sclerosis Rat Model: Possible Underlying Mechanisms.
PMID 38248227 | PMCID PMC10813517 | DOI 10.3390/brainsci14010012 · Brain sciences · 2023 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MBP | “The level of IL17 was detected using ELISA, while the antioxidant genes Nrf2, HO-1 expression at the level of mRNA, expression of the myelin basic protein (MBP), interferon-gamma factor (INF)-γ and tumor necrosis factor (TNF)-α, and apoptotic marker (caspase-3) were measured using immunohistochemistry in the sciatic nerve.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “Vanillic Acid Ameliorates Demyelination in a Cuprizone-Induced Multiple Sclerosis Rat Model: Possible Underlying Mechanisms.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TNF | “The level of IL17 was detected using ELISA, while the antioxidant genes Nrf2, HO-1 expression at the level of mRNA, expression of the myelin basic protein (MBP), interferon-gamma factor (INF)-γ and tumor necrosis factor (TNF)-α, and apoptotic marker (caspase-3) were measured using immunohistochemistry in the sciatic nerve.” | 0.98 | hgnc_dict_v1 |
New Insight into the Possible Roles of L-Carnitine in a Rat Model of Multiple Sclerosis.
PMID 38248238 | PMCID PMC10813446 | DOI 10.3390/brainsci14010023 · Brain sciences · 2023 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MBP | “The expression of myelin basic protein (MBP), IL-1β, p53, iNOS, and NF-KB by immunohistochemistry was detected in the isolated nerves.” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “New Insight into the Possible Roles of L-Carnitine in a Rat Model of Multiple Sclerosis.” | 0.98 | phenotype_alias_lexicon_v2 |
Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis.
PMID 36688131 | PMCID PMC9849768 | DOI 10.3389/fnbeh.2022.1068736 · Frontiers in behavioral neuroscience · 2022 · 2 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MBP | “Luxol Fast Blue (LFB) staining, the expression level of myelin basic protein (MBP), and M1/M2 microglia phenotype genes were assessed in the corpus callosum (CC).” | 0.98 | hgnc_dict_v1 |
| phenotype | multiple sclerosis | “Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis.” | 0.98 | phenotype_alias_lexicon_v2 |