Type	Entity	Source evidence	Confidence	Extractor
gene	MDM2	“Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Cohesive data analysis for the identification of prognostic hub genes and significant pathways associated with HER2 + and TN breast cancer types.”	0.98	phenotype_alias_lexicon_v2
gene	MCC	“Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).”	0.98	hgnc_dict_v1
gene	ACTB	“Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).”	0.98	hgnc_dict_v1

Targeting MDM2-p53 interaction for breast cancer therapy.

PMID 40191734 | PMCID PMC11964874 | DOI 10.32604/or.2025.058956 · Oncology research · 2025 · 3 validated mentions

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Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	MDM2	“To address this issue, advances have been made in therapies targeting molecular pathways related to the murine double minute 2 proto-oncogene (MDM2)-tumor proteinp53 (TP53) interaction.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Targeting MDM2-p53 interaction for breast cancer therapy.”	0.98	phenotype_alias_lexicon_v2
gene	TP53	“To address this issue, advances have been made in therapies targeting molecular pathways related to the murine double minute 2 proto-oncogene (MDM2)-tumor proteinp53 (TP53) interaction.”	0.98	hgnc_dict_v1

Reinvestigation of Passerini and Ugi scaffolds as multistep apoptotic inducers via dual modulation of caspase 3/7 and P53-MDM2 signaling for halting breast cancer.

PMID 37736568 | PMCID PMC10509784 | DOI 10.1039/d3ra04029a · RSC advances · 2023 · 3 validated mentions

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Type	Entity	Source evidence	Confidence	Extractor
gene	MDM2	“The adopted design rationale and synthetic routes relied on mimicking the general thematic features of lead MDM2 inhibitors incorporating multiple aromatic rings.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Reinvestigation of Passerini and Ugi scaffolds as multistep apoptotic inducers via dual modulation of caspase 3/7 and P53-MDM2 signaling for halting breast cancer.”	0.98	phenotype_alias_lexicon_v2
gene	BAX	“Further apoptosis studies revealed that these compounds enhanced gene expression of BAX by 2 folds and suppressed Bcl-2 expression by 4.29-7.75 folds in the treated MCF-7 cells.”	0.98	hgnc_dict_v1

Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma.

PMID 36174446 | DOI 10.1016/j.bioorg.2022.106124 · Bioorganic chemistry · 2022 · 2 validated mentions

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Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	MDM2	“Also, it enhanced the protein expression of apoptotic marker p53 and moderate binding affinity for MDM2 (KD;7.94 μM).”	0.98	hgnc_dict_v1
phenotype	breast cancer	“SP1 did halt the proliferation of breast cancer cells as well as suppressed the metastasis in other organs like liver, lung and heart.”	0.98	phenotype_alias_lexicon_v2

Murine Double Minute 2 Gene (MDM2) rs937283A/G variant significantly increases the susceptibility to breast cancer in Saudi Women.

PMID 33911942 | PMCID PMC8071807 | DOI 10.1016/j.sjbs.2021.01.020 · Saudi journal of biological sciences · 2021 · 5 validated mentions

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Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	MDM2	“Murine Double Minute 2 Gene (MDM2) rs937283A/G variant significantly increases the susceptibility to breast cancer in Saudi Women.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Murine Double Minute 2 Gene (MDM2) rs937283A/G variant significantly increases the susceptibility to breast cancer in Saudi Women.”	0.98	phenotype_alias_lexicon_v2
gene	TP53	“TP53 and its inhibitor the murine double minute 2 (MDM2) genes encode proteins that have crucial functions in the DNA damage response.”	0.98	hgnc_dict_v1
population	Saudi Arabia	“Murine Double Minute 2 Gene (MDM2) rs937283A/G variant significantly increases the susceptibility to breast cancer in Saudi Women. In the present case-control study, the association of MDM2 rs937283A/G polymorphism and breast cancer susceptibility in Saudi women with samples of 137 breast cancer patients, and 98 healthy controls were explored. The results revealed that rs937283A/G variant is significantly increases the risk of breast cancer in Saudi women (p-value = 0.0078). Positive association between increased breast cancer risk and rs937283 variant in premenopausal Saudi women, below 50 years of age, was demonstrated (p-value = 0.0023). Collectively, MDM2 rs937283A/G polymorphism could act as a possible biomarker for breast cancer susceptibility in Saudi women.”	0.95	saudi_context_rules_v1

Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.

PMID 26553387 | DOI 10.1007/s12094-015-1425-5 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016 · 5 validated mentions

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Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	MDM2	“Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.”	0.98	phenotype_alias_lexicon_v2
gene	TP53	“Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.”	0.98	hgnc_dict_v1
variant	R72P	“Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.”	0.82	literature_variant_regex_v2

Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2.

PMID 26521020 | DOI 10.1016/j.etp.2015.10.002 · Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie · 2016 · 4 validated mentions

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Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	MDM2	“Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2.”	0.98	phenotype_alias_lexicon_v2
gene	FADD	“Further, 0.45 and 4.5 μM of violacein increased apoptotic genes, such as Bax, p53, caspase 3, Fas, FADD and markedly reduced Bcl-2 and MDM2 expression levels to two fold when compared to control.”	0.98	hgnc_dict_v1
gene	CDKN1A	“In addition violacein upregulated poly ADP-ribose polymerase (PARP), CDKN1A and caspase-9 significantly (p≤0.05) when compared to control.”	0.98	hgnc_dict_v1

A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.

PMID 21477265 | DOI 10.1111/j.1472-8206.2011.00939.x · Fundamental & clinical pharmacology · 2012 · 5 validated mentions

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Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	MDM2	“The tumor suppressor TP53 and its negative regulator MDM2 play crucial roles in carcinogenesis.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.”	0.98	phenotype_alias_lexicon_v2
gene	TP53	“A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.”	0.98	hgnc_dict_v1
gene	TG	“We found an increased breast cancer risk associated with the MDM2 GG [odds ratio (OR) = 2.79, 95% confidence interval (CI) = 2.04-3.92] and TG [OR = 1.43, 95% CI = 1.12-2.02] genotypes.”	0.98	hgnc_dict_v1

Prognostic relevance of gene amplifications and coamplifications in breast cancer.

PMID 15574759 | DOI 10.1158/0008-5472.CAN-04-1945 · Cancer research · 2004 · 4 validated mentions

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Evidence preview

Type	Entity	Source evidence	Confidence	Extractor
gene	MDM2	“Multiple different oncogenes have been described previously to be amplified in breast cancer including HER2, EGFR, MYC, CCND1, and MDM2.”	0.98	hgnc_dict_v1
phenotype	breast cancer	“Prognostic relevance of gene amplifications and coamplifications in breast cancer.”	0.98	phenotype_alias_lexicon_v2
gene	EGFR	“Multiple different oncogenes have been described previously to be amplified in breast cancer including HER2, EGFR, MYC, CCND1, and MDM2.”	0.98	hgnc_dict_v1
gene	CCND1	“Multiple different oncogenes have been described previously to be amplified in breast cancer including HER2, EGFR, MYC, CCND1, and MDM2.”	0.98	hgnc_dict_v1