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MMP2 and hypertension are reported together in 2 articles.
Gene
MMP2
- HGNC
- HGNC:7166
43articles
43mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 6colorectal cancer 5endometrial cancer 2hypertension 2myocardial infarction 2recurrent pregnancy loss 1rheumatoid arthritis 1thyroid cancer 1
Reported variants (articles · ClinVar status)
Phenotype
Hypertension
828articles
828mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
2 records shown · first 60Polymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central Russia.
PMID 33664351 | PMCID PMC7933364 | DOI 10.1038/s41598-021-84645-4 · Scientific reports · 2021 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP2 | “Eight SNPs of the MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, and MMP12 genes and their gene-gene (epistatic) interactions were analyzed for association with EH in a cohort of 939 patients and 466 controls using logistic regression and assuming additive, recessive, and dominant genetic models.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “Polymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central Russia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MMP1 | “Eight SNPs of the MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, and MMP12 genes and their gene-gene (epistatic) interactions were analyzed for association with EH in a cohort of 939 patients and 466 controls using logistic regression and assuming additive, recessive, and dominant genetic models.” | 0.98 | hgnc_dict_v1 |
| gene | MMP3 | “Eight SNPs of the MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, and MMP12 genes and their gene-gene (epistatic) interactions were analyzed for association with EH in a cohort of 939 patients and 466 controls using logistic regression and assuming additive, recessive, and dominant genetic models.” | 0.98 | hgnc_dict_v1 |
Unraveling the Catha edulis Extract Effects on the Cellular and Molecular Signaling in SKOV3 Cells.
PMID 34040530 | PMCID PMC8141790 | DOI 10.3389/fphar.2021.666885 · Frontiers in pharmacology · 2021 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP2 | “Upstream regulators of cathine and cathinone were found to potentially target several molecules including interleukin-8, MMP2, PLAU, and micro-RNAs.” | 0.98 | hgnc_dict_v1 |
| phenotype | hypertension | “These include teratogenicity and developmental retardation, oral cancer and ulcers, high blood pressure, and myocardial infarction.” | 0.93 | phenotype_alias_lexicon_v2 |
| gene | BAX | “RT-qPCR analysis showed an increase in the gene expression of the apoptotic marker BAX, the tumor suppressor p53, and the inflammatory cytokine IL-6.” | 0.98 | hgnc_dict_v1 |
| gene | FZD8 | “Protein expression analysis by immunostaining showed downregulation of β-catenin, E-cadherin, and Ki-67 and upregulation of FZD8 and SPRY2, suggesting that Wnt and FGF signaling were implicated.” | 0.98 | hgnc_dict_v1 |