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MMP9 and breast cancer are reported together in 11 articles.
Gene
MMP9
- HGNC
- HGNC:7176
75articles
75mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 11hepatocellular carcinoma 7diabetes mellitus 6colorectal cancer 3hypertension 3thyroid cancer 2COVID-19 1cardiomyopathy 1
Reported variants (articles · ClinVar status)
Phenotype
Breast cancer
1,211articles
1,211mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
11 records shown · first 60Erucin Targets Oncogenic Signaling Pathways in Triple-Negative Breast Cancer: An Integrated Network Pharmacology and In Vitro Study.
PMID 42195263 | PMCID PMC13208285 | DOI 10.3390/life16050708 · Life (Basel, Switzerland) · 2026 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Protein-protein interaction analysis identified ten hub genes, including AKT1, STAT3, EGFR, and MMP9, representing highly connected nodes within the predicted interaction network.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Erucin Targets Oncogenic Signaling Pathways in Triple-Negative Breast Cancer: An Integrated Network Pharmacology and In Vitro Study.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | AKT1 | “Protein-protein interaction analysis identified ten hub genes, including AKT1, STAT3, EGFR, and MMP9, representing highly connected nodes within the predicted interaction network.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Protein-protein interaction analysis identified ten hub genes, including AKT1, STAT3, EGFR, and MMP9, representing highly connected nodes within the predicted interaction network.” | 0.98 | hgnc_dict_v1 |
Ethanolic extract of Otostegia fruticosa induces ROS-dependent apoptosis and reduces migration of MDA-MB-231 cells in vitro.
PMID 42189838 | PMCID PMC13210379 | DOI 10.1371/journal.pone.0349314 · PloS one · 2026 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Notably, Otostegia fruticosa downregulated MMP9 and OPN protein expressions, while upregulating caspase-9 and Cyt-c.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Breast cancer (BC) has a highly aggressive and metastatic nature.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | PTEN | “Gene expression analysis by qRT-PCR and immunofluorescence showed altered expressions of genes linked to apoptotic (Caspase-3, 8, 9, and Bcl2, Bax, Bid, Cytochrome c, PTEN) and metastasis (MMP-9) protein.” | 0.98 | hgnc_dict_v1 |
Exploring the landscape of autoimmune disorder-associated genes and their impact on immune microenvironment in breast cancer patients.
PMID 40672619 | PMCID PMC12261193 | DOI 10.62347/EANH4082 · American journal of translational research · 2025 · 10 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Exploring the landscape of autoimmune disorder-associated genes and their impact on immune microenvironment in breast cancer patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CXCR4 | “Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.” | 0.98 | hgnc_dict_v1 |
| gene | CTLA4 | “Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.” | 0.98 | hgnc_dict_v1 |
Preliminary investigation of MMP8 (rs11225395) and MMP9 (rs3787268) polymorphisms association with breast cancer risk in pashtun women of Pakistan.
PMID 39361067 | DOI 10.1007/s11033-024-09968-7 · Molecular biology reports · 2024 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Preliminary investigation of MMP8 (rs11225395) and MMP9 (rs3787268) polymorphisms association with breast cancer risk in pashtun women of Pakistan.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Preliminary investigation of MMP8 (rs11225395) and MMP9 (rs3787268) polymorphisms association with breast cancer risk in pashtun women of Pakistan.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MMP8 | “Preliminary investigation of MMP8 (rs11225395) and MMP9 (rs3787268) polymorphisms association with breast cancer risk in pashtun women of Pakistan.” | 0.98 | hgnc_dict_v1 |
| variant | rs11225395 | “Preliminary investigation of MMP8 (rs11225395) and MMP9 (rs3787268) polymorphisms association with breast cancer risk in pashtun women of Pakistan.” | 0.90 | hgvs_regex_v1 |
Evaluation of oyster mushroom (Pleurotus ostreatus)-derived anthraquinone on the induction of apoptosis and suppression of MMP-2 and MMP-9 expression in breast cancer cells.
PMID 38774755 | PMCID PMC11103395 | DOI 10.7150/ijms.93334 · International journal of medical sciences · 2024 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Treatment with AQ and AQ with paclitaxel consistently decreased the expression of crucial marker genes such as MMP2 and MMP9.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Evaluation of oyster mushroom (Pleurotus ostreatus)-derived anthraquinone on the induction of apoptosis and suppression of MMP-2 and MMP-9 expression in breast cancer cells.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MMP2 | “Treatment with AQ and AQ with paclitaxel consistently decreased the expression of crucial marker genes such as MMP2 and MMP9.” | 0.98 | hgnc_dict_v1 |
| gene | MMP7 | “The mutated genes MMP2, MMP7, and MMP9 were assessed and observed to reveal four putative gene knockdown potentials for breast cancer treatment.” | 0.98 | hgnc_dict_v1 |
Oriental Hornet (Vespa orientalis) Larval Extracts Induce Antiproliferative, Antioxidant, Anti-Inflammatory, and Anti-Migratory Effects on MCF7 Cells.
PMID 34072744 | PMCID PMC8198668 | DOI 10.3390/molecules26113303 · Molecules (Basel, Switzerland) · 2021 · 3 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “The anticancer effect was mediated through (1) induction of apoptosis, as indicated by increased expression of apoptotic genes (Bax, caspase3, and p53) and decreased expression of the anti-apoptotic gene Bcl2; (2) suppression of intracellular reactive oxygen species; (3) elevation of antioxidant enzymes (CAT, SOD, and GPx) and upregulation of the antioxidant regulator Nrf2 and its downstream target HO-1; (4) inhibition of migration as revealed by in vitro wound healing assay and downregulation of the migration-related gene MMP9 and upregulation of the anti-migratory gene TIMP1; and (5) downregulation of inflammation-related genes (NFκB and IL8).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “This study aimed to analyze the effect of aqueous and alcoholic extracts of Vespa orientalis larvae on breast cancer MCF7 cells and investigate the underlying mechanisms.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TIMP1 | “The anticancer effect was mediated through (1) induction of apoptosis, as indicated by increased expression of apoptotic genes (Bax, caspase3, and p53) and decreased expression of the anti-apoptotic gene Bcl2; (2) suppression of intracellular reactive oxygen species; (3) elevation of antioxidant enzymes (CAT, SOD, and GPx) and upregulation of the antioxidant regulator Nrf2 and its downstream target HO-1; (4) inhibition of migration as revealed by in vitro wound healing assay and downregulation of the migration-related gene MMP9 and upregulation of the anti-migratory gene TIMP1; and (5) downregulation of inflammation-related genes (NFκB and IL8).” | 0.98 | hgnc_dict_v1 |
Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival.
PMID 32445177 | PMCID PMC7297818 | DOI 10.1007/s10549-020-05670-x · Breast cancer research and treatment · 2020 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | EGFR | “Elevated MMP9 protein expression correlated significantly with cytokeratin 17 (Ck17), Epidermal Growth Factor Receptor (EGFR), proliferation (Ki67) biomarkers, cell surface adhesion receptor (CD44) and cell division control protein 42 (CDC42).” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Elevated MMP9 protein expression correlated significantly with cytokeratin 17 (Ck17), Epidermal Growth Factor Receptor (EGFR), proliferation (Ki67) biomarkers, cell surface adhesion receptor (CD44) and cell division control protein 42 (CDC42).” | 0.98 | hgnc_dict_v1 |
Correlation between Candidate Single Nucleotide Variants and Several Clinicopathological Risk Factors Related to Breast Cancer in Jordanian Women: A Genotype-Phenotype Study.
PMID 31528229 | PMCID PMC6746117 | DOI 10.7150/jca.33857 · Journal of Cancer · 2019 · 16 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “This study aim to investigate the association of breast cancer risk and prognostic factors with single nucleotide variants of the BRCA1, BRCA2, DAPK1, MMP9, TOX3, and TP53 genes in Jordanian women.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Correlation between Candidate Single Nucleotide Variants and Several Clinicopathological Risk Factors Related to Breast Cancer in Jordanian Women: A Genotype-Phenotype Study.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | BRCA1 | “This study aim to investigate the association of breast cancer risk and prognostic factors with single nucleotide variants of the BRCA1, BRCA2, DAPK1, MMP9, TOX3, and TP53 genes in Jordanian women.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA2 | “This study aim to investigate the association of breast cancer risk and prognostic factors with single nucleotide variants of the BRCA1, BRCA2, DAPK1, MMP9, TOX3, and TP53 genes in Jordanian women.” | 0.98 | hgnc_dict_v1 |
Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells.
PMID 30518369 | PMCID PMC6282398 | DOI 10.1186/s12906-018-2392-5 · BMC complementary and alternative medicine · 2018 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Real-time PCR was used to study the effect of eugenol on the expression of anti-metastatic genes such as MMP2, MMP9, and TIMP-1, and genes involved in apoptosis including Caspase3, Caspase7, and Caspase9.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MMP2 | “Real-time PCR was used to study the effect of eugenol on the expression of anti-metastatic genes such as MMP2, MMP9, and TIMP-1, and genes involved in apoptosis including Caspase3, Caspase7, and Caspase9.” | 0.98 | hgnc_dict_v1 |
| gene | TIMP1 | “Eugenol-treated cells showed significantly decreased MMP2 and MMP9 expression and an insignificant increase in TIMP1 expression in HER2 positive and triple negative breast cancer cells.” | 0.98 | hgnc_dict_v1 |
MicroRNAs and metastasis-related gene expression in Egyptian breast cancer patients.
PMID 22524830 | DOI 10.7314/apjcp.2012.13.2.591 · Asian Pacific journal of cancer prevention : APJCP · 2012 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Mir -10b, mir -21, mir-155 and mir373 and the metastatic genes MMP2, MMP9 and VEGF were significantly associated with an increase in tumor size (P<0.05).” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “MicroRNAs and metastasis-related gene expression in Egyptian breast cancer patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MMP2 | “RESULTS: The BC patients showed an up-regulation in miRNAs (mir-155, mir-10, mir-21 and mir-373) with an upregulation in MMP2, MMp9 and VEGF genes.” | 0.98 | hgnc_dict_v1 |
| gene | TIMP3 | “We found down regulation in mir-17p, mir-126, mir-335, mir-30b and also TIMP3, TMP1 and PDCD4 genes in the cancer tissue compared to the adjacent non-neoplastic tissues.” | 0.98 | hgnc_dict_v1 |
Oleuropein induces anti-metastatic effects in breast cancer.
PMID 23167379 | DOI 10.7314/apjcp.2012.13.9.4555 · Asian Pacific journal of cancer prevention : APJCP · 2012 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “We found that TIMP1,-3, and -4 were over-expressed after all periods of incubation in treated cancer cells compared to untreated cells, while MMP2 and MMP9 genes were down-regulated, at least initially.” | 0.98 | hgnc_dict_v1 |
| phenotype | breast cancer | “Oleuropein induces anti-metastatic effects in breast cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | TIMP1 | “We found that TIMP1,-3, and -4 were over-expressed after all periods of incubation in treated cancer cells compared to untreated cells, while MMP2 and MMP9 genes were down-regulated, at least initially.” | 0.98 | hgnc_dict_v1 |
| gene | MMP2 | “We found that TIMP1,-3, and -4 were over-expressed after all periods of incubation in treated cancer cells compared to untreated cells, while MMP2 and MMP9 genes were down-regulated, at least initially.” | 0.98 | hgnc_dict_v1 |