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MMP9 and infertility are reported together in 1 article.
Gene
MMP9
- HGNC
- HGNC:7176
75articles
75mentions
6variants with confirmed gene link
Most co-reported phenotypes (articles)
breast cancer 11hepatocellular carcinoma 7diabetes mellitus 6colorectal cancer 3hypertension 3thyroid cancer 2COVID-19 1cardiomyopathy 1
Reported variants (articles · ClinVar status)
Phenotype
Infertility
199articles
199mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
1 records shown · first 60A quantitative global proteomics approach to understanding the functional pathways dysregulated in the spermatozoa of asthenozoospermic testicular cancer patients.
PMID 30924599 | DOI 10.1111/andr.12620 · Andrology · 2019 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MMP9 | “Key differentially expressed proteins (DEPs) associated with binding of zona pellucida (CCT3), mitochondrial dysfunction (ATP5A1 and UQCRC2), sperm motility (ATP1A4), and an exosomal protein involved in the metabolic process of the spermatozoa (MMP9) were validated using Western blot analysis by comparing normozoospermic (n = 10) with asthenozoospermic (n = 10) TC patients.” | 0.98 | hgnc_dict_v1 |
| phenotype | infertility | “Furthermore, dysfunctional exosomal pathway may be a possible cause of infertility in TC patients.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | CCT3 | “Key differentially expressed proteins (DEPs) associated with binding of zona pellucida (CCT3), mitochondrial dysfunction (ATP5A1 and UQCRC2), sperm motility (ATP1A4), and an exosomal protein involved in the metabolic process of the spermatozoa (MMP9) were validated using Western blot analysis by comparing normozoospermic (n = 10) with asthenozoospermic (n = 10) TC patients.” | 0.98 | hgnc_dict_v1 |
| gene | UQCRC2 | “Key differentially expressed proteins (DEPs) associated with binding of zona pellucida (CCT3), mitochondrial dysfunction (ATP5A1 and UQCRC2), sperm motility (ATP1A4), and an exosomal protein involved in the metabolic process of the spermatozoa (MMP9) were validated using Western blot analysis by comparing normozoospermic (n = 10) with asthenozoospermic (n = 10) TC patients.” | 0.98 | hgnc_dict_v1 |