Advanced search
Combine gene, variant, phenotype, region and year filters
Every result shows the extracted entities next to the sentences that support them; rows for the searched entities come first.
Transparent by designEvery result links extracted entities to its source sentence and publication identifier.
Knowledge-base search
About your search
MTHFR and obesity are reported together in 6 articles.
Gene
MTHFR
- HGNC
- HGNC:7436
81articles
81mentions
7variants with confirmed gene link
Most co-reported phenotypes (articles)
stroke 9breast cancer 7diabetes mellitus 7coronary artery disease 6hypertension 6obesity 6epilepsy 5autism spectrum disorder 4
Reported variants (articles · ClinVar status)
Phenotype
Obesity
- HPO
- HP:0001513
856articles
856mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
6 records shown · first 60Comprehensive review of thrombophilia: pathophysiology, prevalence, risk factors, and molecular diagnosis.
PMID 40157494 | DOI 10.1016/j.tracli.2025.03.004 · Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MTHFR | “The pathogenesis of thrombophilia involves complex interactions between genetic predispositions, such as mutations in Factor V Leiden, Factor II, MTHFR, and Serpine-1, and environmental factors, including unhealthy lifestyles, prolonged hospitalization, obesity, and cancer.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “The pathogenesis of thrombophilia involves complex interactions between genetic predispositions, such as mutations in Factor V Leiden, Factor II, MTHFR, and Serpine-1, and environmental factors, including unhealthy lifestyles, prolonged hospitalization, obesity, and cancer.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | breast cancer | “These figures surpass the combined annual mortality of AIDS, breast cancer, and motor vehicle accidents.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | COVID-19 | “Additional risk factors include age, family history, and pregnancy, with recent attention to increased susceptibility in SARS-CoV-2 infection.” | 0.93 | phenotype_alias_lexicon_v2 |
Genetic Determinants of Cardiovascular Disease: The Endothelial Nitric Oxide Synthase 3 (eNOS3), Krüppel-Like Factor-14 (KLF-14), Methylenetetrahydrofolate Reductase (MTHFR), MiRNAs27a and Their Association with the Predisposition and Susceptibility to Coronary Artery Disease.
PMID 36431040 | PMCID PMC9697170 | DOI 10.3390/life12111905 · Life (Basel, Switzerland) · 2022 · 12 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MTHFR | “Genetic Determinants of Cardiovascular Disease: The Endothelial Nitric Oxide Synthase 3 (eNOS3), Krüppel-Like Factor-14 (KLF-14), Methylenetetrahydrofolate Reductase (MTHFR), MiRNAs27a and Their Association with the Predisposition and Susceptibility to Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “CAD is caused by genetic and other factors including hypertension, hyperlipidemia, obesity, stress, unhealthy diet, physical inactively, smoking and Type 2 diabetes (T2D).” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | KLF14 | “Conclusion: The MTHFR 677C>T, KLF14 rs972283 G>A, miRNAs27a A>G, and eNOS3 rs1799983 G>T genotypes were associated with CAD susceptibility (p < 0.05).” | 0.98 | hgnc_dict_v1 |
| phenotype | coronary artery disease | “Genetic Determinants of Cardiovascular Disease: The Endothelial Nitric Oxide Synthase 3 (eNOS3), Krüppel-Like Factor-14 (KLF-14), Methylenetetrahydrofolate Reductase (MTHFR), MiRNAs27a and Their Association with the Predisposition and Susceptibility to Coronary Artery Disease.” | 0.98 | phenotype_alias_lexicon_v2 |
Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.
PMID 23267299 | PMCID PMC3523778 | DOI 10.12816/0005968 · International journal of health sciences · 2012 · 7 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MTHFR | “Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “The same was observed among cases-subgroups of hypertension associated with obesity with a notably higher odds ratio (OR=2.6, 95% CI=1.3-5.01, p=0.004).” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | hypertension | “Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “The same was observed among cases-subgroups of hypertension associated with both diabetes and obesity and among cases of hypertension with obesity, also with higher odds ratio (OR=2.6 and 2.2 respectively).” | 0.93 | phenotype_alias_lexicon_v2 |
Methylene tetrahydrofolate reductase (MTHFR) and angiotensinogen converting enzyme (ACE) gene polymorphisms related to overweight and obesity among Saudi patients in Al Qassim.
PMID 23284565 | PMCID PMC3533344 · International journal of health sciences · 2011 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MTHFR | “Methylene tetrahydrofolate reductase (MTHFR) and angiotensinogen converting enzyme (ACE) gene polymorphisms related to overweight and obesity among Saudi patients in Al Qassim.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Methylene tetrahydrofolate reductase (MTHFR) and angiotensinogen converting enzyme (ACE) gene polymorphisms related to overweight and obesity among Saudi patients in Al Qassim.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ACE | “Methylene tetrahydrofolate reductase (MTHFR) and angiotensinogen converting enzyme (ACE) gene polymorphisms related to overweight and obesity among Saudi patients in Al Qassim.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia, Qassim | “Methylene tetrahydrofolate reductase (MTHFR) and angiotensinogen converting enzyme (ACE) gene polymorphisms related to overweight and obesity among Saudi patients in Al Qassim.” | 0.95 | saudi_context_rules_v1 |
Methylene tetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms related to overweight/obesity among Saudi subjects from Qassim Region.
PMID 19893205 | PMCID PMC3835062 | DOI 10.3233/DMA-2009-0660 · Disease markers · 2009 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MTHFR | “BACKGROUND: This work was planned to check for the association of polymorphisms related to methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with overweight/obesity among Saudi subjects from Qassim region.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “Methylene tetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms related to overweight/obesity among Saudi subjects from Qassim Region.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | ACE | “BACKGROUND: This work was planned to check for the association of polymorphisms related to methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with overweight/obesity among Saudi subjects from Qassim region.” | 0.98 | hgnc_dict_v1 |
| population | Saudi Arabia, Qassim | “Methylene tetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms related to overweight/obesity among Saudi subjects from Qassim Region. BACKGROUND: This work was planned to check for the association of polymorphisms related to methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with overweight/obesity among Saudi subjects from Qassim region. METHODS: This work included 130 subjects having overweight or obesity and 111 normal controls. CONCLUSION: There is no solid association of polymorphisms related to MTHFR and ACE genes with non-complicated overweight or obesity among Saudi subjects from Qassim Region.” | 0.95 | saudi_context_rules_v1 |
Thrombophilia in young patients with acute myocardial infarction.
PMID 18176672 · Saudi medical journal · 2008 · 8 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MTHFR | “Traditional risk factors of CAD and protein C, S, antithrombin III deficiencies, factor V Leiden (FV Leiden), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations were investigated.” | 0.98 | hgnc_dict_v1 |
| phenotype | obesity | “RESULTS: There were statistically significant differences in terms of obesity, smoking, triglyceride, total cholesterol, high-density lipoprotein, high-density lipoprotein, and very-low-density lipoprotein cholesterol, family history, hypertension, diabetes, and left ventricular hypertrophy between patients and controls.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | myocardial infarction | “Thrombophilia in young patients with acute myocardial infarction.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | coronary artery disease | “OBJECTIVE: To investigate the association of thrombophilia and coronary artery disease (CAD) in patients with myocardial infarction (MI).” | 0.98 | phenotype_alias_lexicon_v2 |