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MYC and leukemia are reported together in 3 articles.
Gene
MYC
- HGNC
- HGNC:7553
31articles
31mentions
0variants with confirmed gene link
Most co-reported phenotypes (articles)
Phenotype
Leukemia
652articles
652mentions
12co-reported genes shown
Most co-reported genes (articles)
Counts are literature co-mentions in SaudiVarKB, not clinical or causal assertions. Gene details: HGNC; variant status: ClinVar via dbSNP.
Publications
3 records shown · first 60Identification of UBA7 expression downregulation in myelodysplastic neoplasm with SF3B1 mutations.
PMID 40158006 | PMCID PMC11954878 | DOI 10.1038/s41598-025-95738-9 · Scientific reports · 2025 · 4 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MYC | “This work corroborates previous studies, showing significant enrichment of MYC activity and heme metabolism in SF3B1 mutant cells.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Importantly, the clinical relevance of this finding is underscored by the observation that low UBA7 gene expression was associated with poor overall survival in chronic lymphocytic leukemia (CLL), another hematological malignancy with frequent SF3B1 mutations.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | UBA7 | “Identification of UBA7 expression downregulation in myelodysplastic neoplasm with SF3B1 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | SF3B1 | “Identification of UBA7 expression downregulation in myelodysplastic neoplasm with SF3B1 mutations.” | 0.98 | hgnc_dict_v1 |
"Losing the Brakes"-Suppressed Inhibitors Triggering Uncontrolled Wnt/ß-Catenin Signaling May Provide a Potential Therapeutic Target in Elderly Acute Myeloid Leukemia.
PMID 36661526 | PMCID PMC9858232 | DOI 10.3390/cimb45010040 · Current issues in molecular biology · 2023 · 5 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MYC | “Wnt/β-catenin target genes (MYC, MYB, and RUNX1) showed upregulation, while Wnt/β-catenin inhibitors (CXXR, DKK1-4, SFRP1-4, SOST, and WIFI) were suppressed in elderly AML compared to pediatric AML and controls.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “"Losing the Brakes"-Suppressed Inhibitors Triggering Uncontrolled Wnt/ß-Catenin Signaling May Provide a Potential Therapeutic Target in Elderly Acute Myeloid Leukemia.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | MYB | “Wnt/β-catenin target genes (MYC, MYB, and RUNX1) showed upregulation, while Wnt/β-catenin inhibitors (CXXR, DKK1-4, SFRP1-4, SOST, and WIFI) were suppressed in elderly AML compared to pediatric AML and controls.” | 0.98 | hgnc_dict_v1 |
| gene | RUNX1 | “Wnt/β-catenin target genes (MYC, MYB, and RUNX1) showed upregulation, while Wnt/β-catenin inhibitors (CXXR, DKK1-4, SFRP1-4, SOST, and WIFI) were suppressed in elderly AML compared to pediatric AML and controls.” | 0.98 | hgnc_dict_v1 |
Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016.
PMID 27294413 | PMCID PMC4896275 | DOI 10.1186/s40246-016-0063-5 · Human genomics · 2016 · 28 validated mentions
Evidence preview
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | MYC | “Carter O17 Recurrent somatic mutation in the MYC associated factor X in brain tumors H.” | 0.98 | hgnc_dict_v1 |
| phenotype | leukemia | “Snyder P26 Mutant TPMT alleles in children with acute lymphoblastic leukemia from México City and Yucatán, Mexico S.” | 0.98 | phenotype_alias_lexicon_v2 |
| gene | SCN5A | “Karnani, GUSTO study group O4 High-throughput identification of specific qt interval modulating enhancers at the SCN5A locus A.” | 0.98 | hgnc_dict_v1 |
| gene | DDIT4 | “Fogelman O19 DDIT4 gene expression as a prognostic marker in several malignant tumors L.” | 0.98 | hgnc_dict_v1 |